BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55+
SponsorWake Forest University Health Sciences
About this trial
Heart failure with preserved ejection fraction (HFpEF) represents a major public health burden that is both growing rapidly and has few effective therapies. Supervised exercise training (SET) is one of the few effective therapies for older patients with HFpEF, but is currently constrained by cost, resource limitations, and sub-optimal short and long-term clinical response. The objective is to develop and test novel strategies to augment the therapy of exercise training to optimize response and resource utilization in older patients with HFpEF.
Eligibility criteria
Qualifiers
Diagnosis of heart failure with signs and symptoms of heart failure and at least one of the following: Evidence of increased LV filling pressures at rest, exercise, or other provocations / Prior HF hospitalization / Elevated heart Failure with Preserved Ejection Fraction (H2FPEF) score or elevated Heart Failure Association-Pre-test, Echocardiography & natriuretic peptide, Functional testing, Final etiology (HFA-PEFF) score
Left ventricular ejection fraction ≥ 50%
New York Heart Association (NYHA) functional class II-IV
Age ≥ 55 years old
Disqualifiers
Significant change in cardiac medication or heart failure (HF) symptoms within 3 weeks prior to enrollment
Hospitalization or urgent care visit for HF within 4 weeks prior to enrollment
Acute coronary syndrome, stroke, transient ischemic attack; cardiac, carotid or other major Cardiac Vascular (CV) surgery; percutaneous coronary intervention (PCI) or carotid angioplasty, within 30 days prior to enrolment
Uncontrolled hypertension
Trial design
Treatments tested in this trial
- multi-domain behavioral, coaching, and exercise protocol
Treatment groups
14 Participants
are divided into 1 treatment groupLocations
1Wake Forest University Health Sciences27157, Winston-SalemNorth Carolina, United States
Sponsors and collaborators
Wake Forest University Health Sciences
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov