[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541048":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":36,"studyPopulation":23,"armGroups":37,"interventions":58,"overallOfficials":23,"centralContacts":66,"locations":72,"responsibleParty":88,"collaborators":23,"id":90,"slug":23,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":23,"eligibilityCriteria":95,"healthyVolunteers":96,"sex":97,"minAge":98,"maxAge":23,"enrollmentInfo":99,"targetDuration":23,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":23,"overallStatus":74,"whyStopped":23,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Arizona State University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":23},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Intervention effects on brain function using Functional Magnetic Resonance Imaging (fMRI)","Brain connectivity changes such as anterior and posterior cingulate cortex measured by fMRI resting state imaging","The outcome measures are assessed in-person at baseline, 2-4 weeks and 3 months",{"measure":14,"description":15,"timeFrame":12},"Intervention effects on brain white matter using fMRI","Brain white matter changes such as anterior and posterior cingulate cortex measured by fMRI diffusion tensor imaging",{"measure":17,"description":18,"timeFrame":12},"Intervention effects on brain grey matter using fMRI","Brain volume changes such as anterior and posterior cingulate cortex measured by fMRI structural imaging",[20],{"measure":21,"description":22,"timeFrame":12},"Intervention effects on addiction behavior using substance use questionnaires in PhenX Toolkit","Intervention leads to a significant reduction in craving and substance use measured by substance use questionnaires in PhenX Toolkit",null,{"allocation":25,"interventionModel":26,"interventionModelDescription":27,"primaryPurpose":28,"observationalModel":23,"timePerspective":23,"maskingInfo":29},"RANDOMIZED","PARALLEL","mindfulness or\u002Fand active\u002Fsham neurofeedback","BASIC_SCIENCE",{"masking":30,"maskingDescription":23,"whoMasked":31},"QUADRUPLE",[32,33,34,35],"PARTICIPANT","CARE_PROVIDER","INVESTIGATOR","OUTCOMES_ASSESSOR","The proposed study will test whether real-time NF could optimize IBMT practice and improve effects in reducing polysubstance use through targeting self-control networks in the brain.",[38,44,49,53],{"label":39,"type":40,"description":41,"interventionNames":42},"IBMT","EXPERIMENTAL","An evidence-based preventive intervention - integrative body-mind training (IBMT) has shown positive effects in reducing stress and improving self-control and brain plasticity. It has bodifulness and mindfulness components.",[43],"Behavioral: IBMT",{"label":45,"type":40,"description":46,"interventionNames":47},"NF","An evidence-based intervention - NF can not only provide real-time feedback for practice but also target the self-control networks, suggesting the possibility of augmenting IBMT effects via NF.",[48],"Behavioral: NF",{"label":50,"type":40,"description":51,"interventionNames":52},"IBMT + NF","The combined IBMT and NF also show positive effects in reducing substance use.",[43,48],{"label":54,"type":55,"description":56,"interventionNames":57},"Sham NF","SHAM_COMPARATOR","Sham NF has the same settings as the active NF but does not have correct parameters of stimulation.",[48],[59,63],{"type":60,"name":39,"description":61,"armGroupLabels":62,"otherNames":23},"BEHAVIORAL","IBMT is an effortless mindfulness technique",[39,50],{"type":60,"name":45,"description":64,"armGroupLabels":65,"otherNames":23},"NF is a mental training technique.",[50,45,54],[67],{"name":68,"role":69,"phone":70,"phoneExt":23,"email":71},"YiYuan Tang","CONTACT","4807903577","yiyuan@asu.edu",[73],{"facility":68,"status":74,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"RECRUITING","Phoenix","Arizona","85004","United States","US",{"type":81,"coordinates":82},"Point",[83,84],-112.07404,33.44838,{"lat":84,"lon":83},[87],{"name":68,"role":69,"phone":70,"phoneExt":23,"email":71},{"type":89,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100541048",false,"NCT06324786","Brain Mechanisms of Reducing Polysubstance Use","Brain Mechanisms of Reducing Polysubstance Use Following a Novel Body-mind Intervention 2","Inclusion Criteria:\n\n* At least 18 years old\n* Free of any psychiatric diagnoses or medication (besides a substance use disorder (SUD) to alcohol, tobacco, or cannabis)\n* In the past month, at least 4 episodes of heavy episodic drinking; at least 3 occasions of cannabis use; and daily cigarette use for at least the past month\n* Normal or corrected-to-normal vision\n* Written informed consent\n* No previous meditation or NF experiences\n\nExclusion Criteria:\n\n* Any psychiatric diagnoses other than an SUD\n* Medical disorder(s) that may affect the central nervous system; medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)\n* Excluding cannabis, evidence of recent (past month) illicit drug use",true,"ALL","18 Years",{"count":100,"type":101},35,"ESTIMATED","INTERVENTIONAL",[104],"NA","The proposed study will test whether neurofeedback (NF) could optimize integrative body-mind training (IBMT) practice.",[107],"Multiple Drug Use","2026-05-01",{"date":110,"type":111},"2026-05-04","ACTUAL",{"date":113,"type":111},"2023-09-01",{"date":115,"type":101},"2027-08-31",{"name":5,"class":6},1]