[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525894":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":45,"collaborators":20,"id":47,"slug":20,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":20,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":20,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":20,"overallStatus":32,"whyStopped":20,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental group","EXPERIMENTAL","Healthy participants in 3 age groups",[13],"Behavioral: aerobic exercise",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","aerobic exercise","use of single bout of aerobic exercise",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Jacqueline Palmer","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","240-446-1168","brainsinmotion@umn.edu",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Minneapolis","Minnesota","55414","United States",{"type":38,"coordinates":39},"Point",[40,41],-93.26384,44.97997,{"lat":41,"lon":40},[44],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100525894",false,"NCT06127667","Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan","Inclusion Criteria:\n\n* Age within the following 3 group age ranges, 21-30yo; middle-aged: 40-55yo; older: 65-95yo adults\n* the absence of major orthopedic disability\n* cognitively normal (MoCA score ≥ 26\u002F30 in older adult group)\n* vision that is 20\u002F40 or better with or without corrective lenses, (5) the ability to consent and communicate with researchers\n* English speaking\n* ability to stand for 3 minutes and walk 10 meters with or without an assistive device and without the assistance of another person.\n\nExclusion Criteria:\n\n* insulin-dependent diabetes\n* peripheral neuropathy\n* myocardial infarction or symptoms of coronary artery disease within 2 years\n* congestive heart failure or class IV heart failure\n* any significant sensory impairment affecting balance or cognition; visual, vestibular, or auditory impairments.",true,"ALL","21 Years","95 Years",{"count":57,"type":58},102,"ESTIMATED","INTERVENTIONAL",[61],"NA","This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded during standing balance reactions, as well as biological blood samples for genomic analysis.",[64,65],"Neurotypical","Cognitively Normal","2026-03-26",{"date":68,"type":69},"2026-03-27","ACTUAL",{"date":71,"type":69},"2024-10-15",{"date":73,"type":58},"2028-07-01",{"name":5,"class":6},1]