Health Trials

About this trial

BELIEVE is a translational research study that aims to collect samples of breast cancer tissue and blood from individuals undergoing breast cancer treatment (such as chemotherapy, targeted therapy and immunotherapy) before surgery. In certain cases, MRI scans and stool samples will also be obtained before and during treatment. The samples collected from this study will be used for molecular and genetic research to understand why some cancers respond very well to anticancer treatments, and some do not, develop novel ways of accurately measuring response during treatment, as well as identify which patients are at a higher risk of the cancer coming back after surgery.

Eligibility criteria

Qualifiers

Histologically confirmed non-metastatic invasive breast cancer.

Be suitable for, but have not commenced, neoadjuvant chemotherapy, targeted therapy, or immunotherapy.

If HER2-, suitable for treatment with upfront taxane chemotherapy. If HER2+, suitable for treatment with anti-HER2 targeted therapy.

Be aged 18 years and over.

Disqualifiers

Metastatic breast cancer at diagnosis.

Treatment with neoadjuvant endocrine therapy only.

Presence of any psychological, familial or sociological condition potentially hampering compliance with the study protocol and follow-up schedule.

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

No trial groups listed

Locations

1
Royal Marsden NHS Foundation TrustSW3 6JJ, London United Kingdom

Sponsors and collaborators

Royal Marsden NHS Foundation Trust

Lead sponsor

Source ClinicalTrials.gov