[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100386313":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":17,"locations":27,"responsibleParty":43,"collaborators":10,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":10,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"First Affiliated Hospital of Fujian Medical University","OTHER",[8,11,13,15],{"label":9,"type":10,"description":10,"interventionNames":10},"CADASIL patients",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Asymptomatic carriers of CADASIL",{"label":14,"type":10,"description":10,"interventionNames":10},"Relatives of CADASIL patients and carriers",{"label":16,"type":10,"description":10,"interventionNames":10},"Unrelated healthy controls",[18,24],{"name":19,"role":20,"phone":21,"phoneExt":22,"email":23},"Lin Yi, PhD","CONTACT","13615039153","86","caibin929@163.com",{"name":25,"role":20,"phone":26,"phoneExt":10,"email":23},"Cai Bin, PhD","13338413842",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Department of Neurology , First Affiliated Hospital Fujian Medical University","RECRUITING","Fuzhou","Fujian","350004","China",{"type":36,"coordinates":37},"Point",[38,39],119.30611,26.06139,{"lat":39,"lon":38},[42],{"name":25,"role":20,"phone":26,"phoneExt":22,"email":23},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Bin Cai","Professor","100386313",false,"NCT04310098","CADASIL Registry Study","Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Registry Study","Inclusion Criteria:\n\n1. Sign informed consent.\n2. Age\\>18\n3. Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy\n4. Asymptomatic NOTCH3 mutation carriers\n5. Relatives of CADASIL patients or carriers\n6. Unrelated healthy controls\n\nExclusion Criteria:\n\n1. Unable to cooperate with inspectors\n2. Serious systemic illness, such as heart, liver, kidney disease or major mental illness\n3. Contraindications for imaging examination",true,"ALL","18 Years","85 Years",{"count":58,"type":59},1000,"ESTIMATED","OBSERVATIONAL","The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.",[63],"Cadasil","2023-09-26",{"date":66,"type":67},"2023-09-28","ACTUAL",{"date":69,"type":67},"2020-03-09",{"date":71,"type":59},"2049-03-09",{"name":45,"class":6},1]