[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642200":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":25,"locations":25,"responsibleParty":34,"collaborators":25,"id":36,"slug":25,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":25,"eligibilityCriteria":41,"healthyVolunteers":42,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":25,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":59,"whyStopped":25,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":25},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Calibre First Sequence","EXPERIMENTAL","Participants undergo cardiopulmonary exercise testing using the investigational Calibre device during Visit 1, followed by testing with the COSMED Quark CPET reference system during Visit 2 (at least 2 days later).",[13],"Device: Calibre Biometrics",{"label":15,"type":10,"description":16,"interventionNames":17},"COSMED First Sequence","Participants undergo cardiopulmonary exercise testing using the COSMED Quark CPET reference system during Visit 1, followed by testing with the investigational Calibre device during Visit 2 (at least 2 days later).",[18],"Device: COSMED Quark CPET metabolic cart",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","COSMED Quark CPET metabolic cart","FDA-cleared cardiopulmonary exercise testing (CPET) metabolic cart used as the reference comparator for measurement of respiratory gas exchange and ventilatory parameters during ramp cycle ergometry. Participants wear a facemask connected to the system for breath-by-breath measurement of oxygen consumption (VO2), carbon dioxide production (VCO2), minute ventilation (VE), anaerobic threshold, and ventilatory efficiency during maximal exercise testing.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Calibre Biometrics","Investigational wearable facemask device with integrated sensors for breath-by-breath measurement of respiratory gas exchange and ventilatory parameters during cardiopulmonary exercise testing, evaluated against the COSMED Quark CPET reference system.",[9],[31],{"name":32,"affiliation":5,"role":33},"David MacLeod, M.B.B.S.","PRINCIPAL_INVESTIGATOR",{"type":35,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100642200",false,"NCT07596108","Calibre vs. COSMED","Correlation of Cardiopulmonary Exercise Testing (CPET) VO2 Max Parameters Between the Calibre Device and COSMED Metabolic Cart","Inclusion Criteria:\n\n* Age 18-55\n* Able to speak English\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Acute myocardial infarction\n* Unstable angina\n* Syncope\n* Uncontrolled asthma\n* Arterial desaturation at rest on room air \\\u003C85%\n* Severe untreated arterial hypertension at rest (\\>200 mm Hg systolic, \\>120 mm Hg diastolic)\n* Significant pulmonary hypertension\n* Active thrombosis of the lower extremity, unless treated for at least 2 weeks prior to participation.\n* Within 2 weeks of acute symptomatic pulmonary embolus\n* Considered inappropriate to participate by Principal Investigator\n* Previously experienced a heart attack\n* Pregnancy",true,"ALL","18 Years","55 Years",{"count":47,"type":48},40,"ESTIMATED","INTERVENTIONAL",[51],"NA","This study evaluates agreement between the Calibre device and the COSMED Quark CPET system for measurement of cardiorespiratory fitness parameters during maximal exercise testing in adults aged 18-55 years.",[54],"Cardiorespiratory Fitness",[56,57,58],"Cardiopulmonary Exercise Testing","VO2 Max","Exercise Physiology","NOT_YET_RECRUITING","2026-06-16",{"date":62,"type":63},"2026-06-17","ACTUAL",{"date":65,"type":48},"2026-09",{"date":67,"type":48},"2027-07",{"name":5,"class":6}]