[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557031":3},{"organization":4,"outcomesModule":7,"designInfo":23,"detailedDescription":27,"studyPopulation":28,"armGroups":24,"interventions":29,"overallOfficials":24,"centralContacts":36,"locations":42,"responsibleParty":65,"collaborators":24,"id":69,"slug":24,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":24,"enrollmentInfo":77,"targetDuration":24,"studyType":80,"phases":24,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University Hospital Bispebjerg and Frederiksberg","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":18},[9],{"measure":10,"description":11,"timeFrame":12},"number of rehospitalizations","number of emergency rehospitalizations, classified according to:\n\n1. new decompensation of heart failure\n2. side effects \u002F complications to therapy for heart failure\n3. other","up to six months after discharge from index admission",[14],{"measure":15,"description":16,"timeFrame":17},"Heart rate Variability change from admission to discharge","Measurement of heart-rate oscillations over a short term (30 min) of continuous three-lead electrocardiogram recording divided into two time domains:\n\nDomain 10min: relaxed, supine position for 10 min Domain 30 min: comprising the first 10 min-domain in addition to stand-up and walking for 5 min, followed by sitting relaxed until completing 30 min recording in total","repeated measurement at baseline (within 48h from time of index admission) and before discharge (estimated one week on average from index admission)",[19],{"measure":20,"description":21,"timeFrame":22},"Diastolic function","Measurement of changes diastolic function in right and left ventricle based on wavelet-ECG measurements","six months",{"allocation":24,"interventionModel":24,"interventionModelDescription":24,"primaryPurpose":24,"observationalModel":25,"timePerspective":26,"maskingInfo":24},null,"COHORT","PROSPECTIVE","If the patient accepts to participate and signed the project informed consent, their clinical record will be followed until the last patient included has been followed for six months.","Patients admitted to the hospital with acute decompensated heart failure, regardless of measured left ventricle ejection fraction.\n\nPatients will be grouped according to rhythm: sinus rhythm and atrial fibrillation.",[30],{"type":31,"name":32,"description":33,"armGroupLabels":24,"otherNames":34},"DIAGNOSTIC_TEST","heart monitoring","individual comparison of heart rate variability at admission with a repeated measurement before discharge",[35],"heart rate variability",[37],{"name":38,"role":39,"phone":40,"phoneExt":24,"email":41},"Helena Dominguez","CONTACT","22989343","mdom0002@regionh.dk",[43],{"facility":44,"status":45,"city":46,"state":24,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Cardiology department Y, Bispebjerg-Frederiksberg Hospital","RECRUITING","Frederiksberg","2000","Denmark","DK",{"type":51,"coordinates":52},"Point",[53,54],12.53463,55.67938,{"lat":54,"lon":53},[57,61],{"name":58,"role":39,"phone":59,"phoneExt":60,"email":41},"Helena Dominguez, MD, PhD","+4538163916","6068",{"name":62,"role":39,"phone":63,"phoneExt":24,"email":64},"Christoffer V Madsen, MD","+4520661178","cmad0140@regionh.dk",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Helena DOMINGUEZ","MD, PhD, Consultant, Assoc.Prof.","100557031",false,"NCT06532825","Cardiac Autonomic Dysfunction As a Sign of Irreversible Advanced Heart Failure","CADYSH","Inclusion Criteria:\n\n* 18-years age or older\n* admitted with acute decompensated heart failure for less than 48 h\n\nExclusion Criteria:\n\n* pacemaker\n* not signed informed consent\n* other heart rhythm than sinus rhythm or atrial fibrillation","ALL","18 Years",{"count":78,"type":79},200,"ESTIMATED","OBSERVATIONAL","The main hypothesis is that autonomic dysfunction cannot improve among patients reaching end-stage heart failure. To evaluate this, patients admitted with acute decompensated heart failure in Bispebjerg hospital, and history one or more admissions with the same condition within the prior year, will undergo repeated brief heart monitoring (10 min). Baseline recordings (at admission) will be compared with equivalent measurements before discharge to explore whether heart rate variability increases. Patients will be followed for six months after discharge from the hospital.",[83],"Heart Failure",[85,86],"heart failure","decompensated","2025-02-22",{"date":89,"type":90},"2025-02-25","ACTUAL",{"date":92,"type":90},"2024-08-01",{"date":94,"type":79},"2025-12-31",{"name":5,"class":6},1]