Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorFlorida State University
About this trial
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
Eligibility criteria
Qualifiers
Between the ages of 18 and 65
Able to provide informed consent
Have normal to corrected vision
Willing to comply with all study procedures and be available for the duration of the study
Disqualifiers
ADHD (currently under treatment)
Neurological disorders and conditions including, but not limited to history of epilepsy; seizures, except childhood febrile seizures; dementia; history of stroke; Parkinson's disease, multiple sclerosis, cerebral aneurysm; brain tumors
Medical or neurological illness or treatment for a medical disorder that could interfere with study participation. For example, unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment
Prior brain surgery
Trial design
Treatments tested in this trial
- Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
- Theta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
- Sham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
Treatment groups
72 Participants
are divided into 3 treatment groupsLocations
1Florida State University32306, TallahasseeFlorida, United States
Sponsors and collaborators
Florida State University
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator
Source ClinicalTrials.gov