[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100356308":3},{"organization":4,"outcomesModule":7,"designInfo":38,"detailedDescription":41,"studyPopulation":42,"armGroups":24,"interventions":24,"overallOfficials":43,"centralContacts":48,"locations":54,"responsibleParty":69,"collaborators":72,"id":75,"slug":24,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":24,"maxAge":24,"enrollmentInfo":82,"targetDuration":24,"studyType":85,"phases":24,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Capital Medical University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":33,"otherOutcomes":24},[9,13,16,19,22,25,27,29,31],{"measure":10,"description":11,"timeFrame":12},"Death rate","A combination of death form of all causes","1 year from baseline",{"measure":14,"description":15,"timeFrame":12},"Functional independence","Defined as modified Rankin score (0-5) equal to or lower than 2",{"measure":17,"description":18,"timeFrame":12},"Recurrence of cerebral venous sinus thrombosis, deep cerebral venous thrombosis and cortical vein thrombosis","Diagnosed by DSA, MRV, CTV or HR-MRI",{"measure":20,"description":21,"timeFrame":12},"Incidence of hemorrhagic complication","Extracranial hemorrhage (fall in hemoglobin of 2 gram\u002Fdl or more within 48 hours) or intracranial hemorrhage",{"measure":23,"description":24,"timeFrame":12},"Incidence of sinus wall rupture",null,{"measure":26,"description":24,"timeFrame":12},"Incidence of acute ischemic stroke",{"measure":28,"description":24,"timeFrame":12},"Incidence of acute myocardial infarction",{"measure":30,"description":24,"timeFrame":12},"Incidence of pulmonary embolism",{"measure":32,"description":24,"timeFrame":12},"Incidence of deep venous thrombosis",[34,36],{"measure":35,"description":24,"timeFrame":12},"Incidence of epilepsy",{"measure":37,"description":24,"timeFrame":12},"Incidence of allergic reaction",{"allocation":24,"interventionModel":24,"interventionModelDescription":24,"primaryPurpose":24,"observationalModel":39,"timePerspective":40,"maskingInfo":24},"COHORT","PROSPECTIVE","cerebral venous thrombosis (CVT) is caused by a clot in the cerebral vein, which resulted in an obstruction of the blood outflow. CVT mainly includes cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis. However, the epidemiological features of CVT in China mainland remained obscure. This study was aimed to establish a multicenter cohort recruiting patients with CVT across 31 provinces and municipalities in China mainland. Clinical features,natural history of the diseases and current therapeutic situations will be analyzed to reveal the epidemiological features of CVT. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT. Patients will be followed-up at 1, 3, 6, 12 months from baseline to evaluate the clinical prognosis and therapeutic outcomes.","Patients with cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis.",[44],{"name":45,"affiliation":46,"role":47},"Xunming Ji, MD, PhD","Xuanwu Hospital, Beijing","PRINCIPAL_INVESTIGATOR",[49],{"name":50,"role":51,"phone":52,"phoneExt":24,"email":53},"Min Li, MD, PhD","CONTACT","+86-18701519698","812879698@qq.com",[55],{"facility":56,"status":57,"city":58,"state":24,"zip":24,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Xuanwu Hospital, Capital Medical University","RECRUITING","Beijing","China","CN",{"type":62,"coordinates":63},"Point",[64,65],116.39723,39.9075,{"lat":65,"lon":64},[68],{"name":50,"role":51,"phone":24,"phoneExt":24,"email":24},{"type":47,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Ji Xunming,MD,PhD","Professor",[73],{"name":74,"class":6},"Beijing Municipal Science & Technology Commission","100356308",false,"NCT03919305","Cerebral Venous Thrombosis Cohort Study in China Mainland","CCC","Inclusion Criteria:\n\n• Cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis diagnosed by digital subtraction angiography (DSA), magnetic resonance venography (MRV), computed tomography venography (CTV) or high-resolution magnetic resonance imaging (HR-MRI).\n\nExclusion Criteria:\n\n• None of the patient, trustee or immediate family members signed the informed consent.","ALL",{"count":83,"type":84},3000,"ESTIMATED","OBSERVATIONAL","This study was aimed to reveal the clinical features,natural history of the diseases and current therapeutic situations of cerebral venous thrombosis (CVT) in China mainland. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT.",[88,89,90],"Cerebral Venous Sinus Thrombosis","Deep Cerebral Vein Thrombosis","Cortical Vein Thrombosis",[92,93,94,95,96,97,98,99],"Cerebral venous sinus thrombosis","Deep cerebral vein thrombosis","Cortical vein thrombosis","Cohort study","Real world evidence","Observational study","China mainland","Cerebral venous system thrombosis","2026-05-29",{"date":102,"type":103},"2026-06-02","ACTUAL",{"date":105,"type":103},"2019-01-01",{"date":107,"type":84},"2026-12-31",{"name":5,"class":6},1]