[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577147":3},{"organization":4,"outcomesModule":7,"designInfo":36,"detailedDescription":35,"studyPopulation":35,"armGroups":41,"interventions":58,"overallOfficials":35,"centralContacts":35,"locations":69,"responsibleParty":101,"collaborators":35,"id":103,"slug":35,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":35,"eligibilityCriteria":108,"healthyVolunteers":109,"sex":110,"minAge":111,"maxAge":35,"enrollmentInfo":112,"targetDuration":35,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":35,"overallStatus":121,"whyStopped":35,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},{"fullName":5,"class":6},"Universidade Nova de Lisboa","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":25,"otherOutcomes":35},[9,13,16,19,22],{"measure":10,"description":11,"timeFrame":12},"Changes in the iAUC (mmol\u002FL*min) for total amino acids","Total amino acids will be measured in fasting and every 30 minutes up to 180 minutes. The iAUC (mmol\u002FL\\*min) for amino acids will be calculated based on the concentration curve following consumption of the test meal.","180 minutes",{"measure":14,"description":15,"timeFrame":12},"Changes in the iAUC (pmol\u002FL*min) for glucagon-like peptide-1 (GLP-1)","GLP-1 will be measured in fasting and every 30 minutes up to 180 minutes. The iAUC (pmol\u002FL\\*min) for GLP-1 will be calculated based on the concentration curve following consumption of the test meal.",{"measure":17,"description":18,"timeFrame":12},"Changes in the iAUC (pmol\u002FL*min) for Cholecystokinin (CCK)","CCK will be measured in fasting and every 30 minutes up to 180 minutes. The iAUC (pmol\u002FL\\*min) for CCK will be calculated based on the concentration curve following consumption of the test meal.",{"measure":20,"description":21,"timeFrame":12},"Changes in the iAUC (pmol\u002FL*min) for peptide YY (PYY)","PYY will be measured in fasting and every 30 minutes up to 180 minutes. The iAUC (pmol\u002FL\\*min) for PYY will be calculated based on the concentration curve following consumption of the test meal.",{"measure":23,"description":24,"timeFrame":12},"Changes in the iAUC (pmol\u002FL*min) for Gastric inhibitory polypeptide (GIP)","GIP will be measured in fasting and every 30 minutes up to 180 minutes. The iAUC (pmol\u002FL\\*min) for GIP will be calculated based on the concentration curve following consumption of the test meal.",[26,29,32],{"measure":27,"description":28,"timeFrame":12},"Changes in glucose","Glucose will be measured in fasting and every 30 minutes up to 3 hours. The iAUC (mmol\u002FL\\*min) for glucose will be calculated based on the concentration curve following consumption of the test meal.",{"measure":30,"description":31,"timeFrame":12},"Changes in insulin","Insulin will be measured in fasting and every 30 minutes up to 3 hours. The iAUC (mmol\u002FL\\*min) for insulin will be calculated based on the concentration curve following consumption of the test meal.",{"measure":33,"description":34,"timeFrame":12},"Changes in C-peptide","C-peptide will be measured in fasting and every 30 minutes up to 3 hours. The iAUC (mmol\u002FL\\*min) for C-peptide will be calculated based on the concentration curve following consumption of the test meal.",null,{"allocation":37,"interventionModel":38,"interventionModelDescription":35,"primaryPurpose":6,"observationalModel":35,"timePerspective":35,"maskingInfo":39},"RANDOMIZED","CROSSOVER",{"masking":40,"maskingDescription":35,"whoMasked":35},"NONE",[42,48,53],{"label":43,"type":44,"description":45,"interventionNames":46},"Meal A","EXPERIMENTAL","Meal A - CGMP-AAs alone",[47],"Dietary Supplement: cGMP-AAs alone (20 g of protein equivalent)",{"label":49,"type":44,"description":50,"interventionNames":51},"Meal B","Meal B - CGMP-AAs in combination with carbohydrates (including fibre)",[52],"Dietary Supplement: cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple",{"label":54,"type":44,"description":55,"interventionNames":56},"Meal C","Meal C - CGMP-AAs in combination with carbohydrates and fat",[57],"Dietary Supplement: cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil",[59,63,66],{"type":60,"name":61,"description":61,"armGroupLabels":62,"otherNames":35},"DIETARY_SUPPLEMENT","cGMP-AAs alone (20 g of protein equivalent)",[43],{"type":60,"name":64,"description":64,"armGroupLabels":65,"otherNames":35},"cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 160 g of unpeeled apple",[49],{"type":60,"name":67,"description":67,"armGroupLabels":68,"otherNames":35},"cGMP-AAs (20 g of protein equivalent) + 50 g of low-protein bread + 10 g of olive oil",[54],[70],{"facility":71,"status":35,"city":72,"state":35,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":82},"NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa,","Lisbon","1169-056","Portugal","PT",{"type":77,"coordinates":78},"Point",[79,80],-9.1498,38.72509,{"lat":80,"lon":79},[83,88,91,94,95,97,100],{"name":84,"role":85,"phone":86,"phoneExt":35,"email":87},"Ana Faria, PhD","CONTACT","00351218803033","ana.faria@nms.unl.pt",{"name":89,"role":85,"phone":86,"phoneExt":35,"email":90},"Catarina Rodrigues, MSc","catarina.rodrigues@nms.unl.pt",{"name":92,"role":93,"phone":35,"phoneExt":35,"email":35},"Júlio César Rocha, PhD","PRINCIPAL_INVESTIGATOR",{"name":84,"role":93,"phone":35,"phoneExt":35,"email":35},{"name":96,"role":93,"phone":35,"phoneExt":35,"email":35},"Anita MacDonald, PhD",{"name":98,"role":99,"phone":35,"phoneExt":35,"email":35},"Conceição Calhau, PhD","SUB_INVESTIGATOR",{"name":89,"role":99,"phone":35,"phoneExt":35,"email":35},{"type":102,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100577147",false,"NCT06794515","cGMP: Metabolism and Appetite Modulation","Metabolic Effects of cGMP: From Amino Acid Absorption Kinetics to Appetite Modulation","Inclusion Criteria:\n\n* Men or women\n* Adults (age ≥ 18 years)\n* Body Mass Index (BMI) between 18.5-25.0 kg\u002Fm2\n* Filling informed consent\n\nExclusion Criteria:\n\n* Clinically significant illness\n* Have changed frequency, duration, or intensity of physical activity in the last month\n* Taking protein supplements\n* Pregnant or breastfeeding\n* Smoking and drug use",true,"ALL","18 Years",{"count":113,"type":114},15,"ESTIMATED","INTERVENTIONAL",[117],"NA","Phenylketonuria is an inborn error of phenylalanine metabolism. Although the phenylalanine-restricted diet is recognized as the mainstay of therapy, little is known about the impact of protein substitutes on the metabolism of patients with phenylketonuria.\n\nTherefore, the aim of this project is to study the impact of acute ingestion of casein glycomacropeptide supplemented with amino acids (cCGMP-AAs) alone or in combination with two different meals on amino acid absorption kinetics, glycaemic and insulinemic response, and on acute markers of appetite control.\n\nThe main findings of this project will bring new insights into the dietary management of these patients, which may lead to improvements in protein substitutes formulations.",[120],"Healthy","NOT_YET_RECRUITING","2025-01-20",{"date":124,"type":125},"2025-01-27","ACTUAL",{"date":127,"type":114},"2025-02-03",{"date":129,"type":114},"2025-04-24",{"name":5,"class":6},1]