[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100463159":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":10,"id":56,"slug":10,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":10,"enrollmentInfo":64,"targetDuration":67,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"PEA cohort",null,"patients with CTEPH receiving PEA",[13],"Procedure: pulmonary endarterectomy or balloon pulmonary angioplasty",{"label":15,"type":10,"description":16,"interventionNames":17},"BPA cohort","patients with CTEPH receiving BPA",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Pulmonary arterial hypertension (PAH)-specific medication","CTEPH patients without PEA or BPA, treatment with any PAH-specific medication, i.e. endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, soluble guanylate cyclase stimulators, drugs acting on the prostanoid pathway and prostaglandin I2 receptor agonists",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"PROCEDURE","pulmonary endarterectomy or balloon pulmonary angioplasty","A multidisciplinary team make the final treatments for patients with CTEPH depending on their disease and preferences.",[15,9,19],[29],"PEA or BPA",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhenguo Zhai, Ph.D.","CONTACT","+86 10 84206269","zhaizhenguo2011@126.com",[37],{"facility":38,"status":39,"city":40,"state":10,"zip":41,"country":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"China-Japan Frendship hospital","RECRUITING","Beijing","100029","China",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},[50],{"name":51,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhenguo Zhai, Ph D",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhenguo Zhai,MD,PhD","Principal Investigator","100463159",false,"NCT05311072","Change-a Multi-center Chronic Thromboembolic Pulmonary Hypertension （CTEPH） Database in China","A Chinese Real-world Study to Investigate the Management Pattern and Outcomes of Chronic Thromboembolic Pulmonary Hypertension (CHANGE Study)","Inclusion Criteria:\n\n1. Patients must be diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH)\n2. Patients must be willing to provide informed consent\n3. Patients must meet the following criteria for CTEPH:\n\na mean pulmonary artery pressures (mPAP) ≥20 mmHg combined with a pulmonary vascular resistance (PVR) ≥ 3 WU and pulmonary arterial wedge pressure (PAWP)≤ 15 mmHg documented at right heart catheterization with radiographic evidence of organized thrombi involving the pulmonary arteries after 3 months of effective anticoagulation.\n\nExclusion Criteria:\n\n1. Main cause of PH other than CTEPH\n2. Participation in a therapeutic clinical trial with an unknown drug;\n3. Withdrawal or lack of informed consent.","ALL","14 Years",{"count":65,"type":66},1500,"ESTIMATED","3 Years","OBSERVATIONAL","The Change Database is a prospective, observational multi-center disease registry, which will collect data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China. It aims to illustrate the epidemiology, management and long-term outcomes of CTEPH.",[71],"Chronic Thromboembolic Pulmonary Hypertension",[71,73,74,75,76,77,78],"epidemiology","diagnosis","treatment","prognosis","balloon pulmonary angioplasty","pulmonary endarterectomy","2024-01-20",{"date":81,"type":82},"2024-01-23","ACTUAL",{"date":84,"type":82},"2015-10-01",{"date":86,"type":66},"2027-12-31",{"name":5,"class":6},1]