[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644063":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":44,"collaborators":10,"id":47,"slug":10,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":10,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":10,"studyType":58,"phases":10,"briefSummary":59,"conditions":60,"keywords":10,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Long-term survival (LTS) group",null,"patients with overall survival of more than 5 years after initial immunotherapy",{"label":13,"type":10,"description":14,"interventionNames":10},"Short-term survival (STS) group","patients with overall survival of less than 1 year after initial immunotherapy",[16],{"name":17,"affiliation":5,"role":18},"Jie Wang, MD, PhD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Jie Wang, MD,PhD","CONTACT","8610-87788029","zlhuxi@163.com",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Jie Zhao, MD","17801204737","zhaojie_12@163.com",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":10,"country":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Cancer Hospital Chinese Academy of Medical Sciences","RECRUITING","Beijing","China",{"type":36,"coordinates":37},"Point",[38,39],116.39723,39.9075,{"lat":39,"lon":38},[42,43],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},{"type":18,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jie Wang","Chief of Medical Oncology","100644063",false,"NCT07668037","Characterization of Multi-Omics Landscapes and AI Pathological Prediction Model for Long-Term Survival in NSCLC Immunotherapy","Characterization of Multi-Omics Landscapes in Long-Term Survival Following Immunotherapy and Development of an AI Pathological Prediction Model for Long-Term Survival Based on H&E-Stained Images in Advanced Non-Small Cell Lung Cancer","Inclusion Criteria:\n\n* Patients with pathologically confirmed advanced or locally advanced non-small cell lung cancer (NSCLC).\n* Patients derived from real-world data of multiple centers (including Cancer Hospital, Chinese Academy of Medical Sciences; Cancer Hospital of Shanxi, Chinese Academy of Medical Sciences \\[Shanxi Cancer Hospital\\]; and other participating centers) or from completed phase III clinical trials (e.g., Choice-01, Rationale-307, Rationale-304).\n* Patients who received first-line or later-line immune checkpoint inhibitor (ICI) monotherapy or ICI-based combination therapy.\n* Patients with complete clinical information and available follow-up data.\n\nExclusion Criteria:\n\n* Patients whose systemic therapy did not include an immunotherapy regimen.\n* Patients lost to follow-up.","ALL","18 Years",{"count":56,"type":57},600,"ESTIMATED","OBSERVATIONAL","This study is a retrospective, multicenter, observational cohort study in patients with advanced or locally advanced non-small cell lung cancer (NSCLC). The aim of this study was to establish a long-term survival (LTS) versus short-term survival (STS) real-world cohort, to systematically characterize the multi-omics landscapes, and to develop and validate an artificial intelligence (AI) pathological prediction model based on routine H\\&E-stained images for predicting immune microenvironment features and long-term survival outcomes following immunotherapy.",[61,62,63],"Non-Small Cell Carcinoma of Lung","Immunotherapy","Advanced Non-Small Cell Lung Cancer","2026-06-22",{"date":66,"type":67},"2026-06-25","ACTUAL",{"date":69,"type":67},"2026-05-01",{"date":71,"type":57},"2030-05-01",{"name":5,"class":6},1]