[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100142079":3},{"organization":4,"outcomesModule":7,"designInfo":13,"detailedDescription":16,"studyPopulation":17,"armGroups":18,"interventions":11,"overallOfficials":25,"centralContacts":29,"locations":34,"responsibleParty":492,"collaborators":494,"id":508,"slug":11,"hasResults":509,"nctId":510,"briefTitle":511,"officialTitle":511,"acronym":11,"eligibilityCriteria":512,"healthyVolunteers":513,"sex":514,"minAge":11,"maxAge":11,"enrollmentInfo":515,"targetDuration":11,"studyType":518,"phases":11,"briefSummary":519,"conditions":520,"keywords":522,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":530,"completionDateStruct":532,"leadSponsor":534,"locationsCount":535},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":11,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.",null,"25 years",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":14,"timePerspective":15,"maskingInfo":11},"COHORT","RETROSPECTIVE","The study will focus on the following objectives:\n\n* Characterize survivors' health with respect to disease- and treatment-related factors.\n* Investigate the consequences of various intensities of exposure to chemotherapy and\u002For radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…).\n* Compare the mortality experience of survivors with the general population.\n* Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors.\n* Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes.\n* Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.","Newly diagnosed with cancer between January 1, 1970 and December 31, 1999 at one of the participating centers noted below or identified as sibling control.",[19,22],{"label":20,"type":11,"description":21,"interventionNames":11},"Cancer survivors","Survivors of cancer, diagnosed under 21 years of age, between 1970 and 1999 This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and\u002For surgery, for an increased risk of late-occurring events associated with excess mortality and morbidity.",{"label":23,"type":11,"description":24,"interventionNames":11},"Sibling Controls","A group of sibling controls will be identified to provide: (1) the ability to make direct comparisons with the survivors, (2) data on outcomes in a non-cancer population, and (3) additional comparison group to determine consistency of findings between data sources.",[26],{"name":27,"affiliation":5,"role":28},"Gregory T. Armstrong, MD, MSCE","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":11,"email":33},"CONTACT","888-226-4343","referralinfo@stjude.org",[35,55,71,86,98,113,128,143,160,176,192,208,219,235,251,267,283,290,299,316,332,346,363,379,394,407,417,432,447,458,474],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Alabama at Birmingham\u002FChildren's of Alabama","RECRUITING","Birmingham","Alabama","35294","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-86.80249,33.52066,{"lat":47,"lon":46},[50,54],{"name":51,"role":31,"phone":52,"phoneExt":11,"email":53},"Kimberly Whelan, MD","202-939-9285","kwhelan@peds.uab.edu",{"name":51,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":56,"status":37,"city":57,"state":58,"zip":59,"country":41,"countryCode":42,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"City of Hope National Medical Center","Duarte","California","91010",{"type":44,"coordinates":61},[62,63],-117.97729,34.13945,{"lat":63,"lon":62},[66,70],{"name":67,"role":31,"phone":68,"phoneExt":11,"email":69},"Saro Armenian, DO","626-471-7205","sarmenian@coh.org",{"name":67,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":72,"status":37,"city":73,"state":58,"zip":74,"country":41,"countryCode":42,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Children's Hospital Los Angeles","Los Angeles","90027",{"type":44,"coordinates":76},[77,78],-118.24368,34.05223,{"lat":78,"lon":77},[81,85],{"name":82,"role":31,"phone":83,"phoneExt":11,"email":84},"David Freyer, DO","323-361-8953","DFreyer@chla.usc.edu",{"name":82,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":87,"status":37,"city":73,"state":58,"zip":88,"country":41,"countryCode":42,"cosmosGeoPoint":89,"geoPoint":91,"contacts":92},"University of California-Los Angeles","90095",{"type":44,"coordinates":90},[77,78],{"lat":78,"lon":77},[93,97],{"name":94,"role":31,"phone":95,"phoneExt":11,"email":96},"Jacqueline Casillas, MD","310-794-2474","jcasillas@mednet.ucla.edu",{"name":94,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":99,"status":37,"city":100,"state":58,"zip":101,"country":41,"countryCode":42,"cosmosGeoPoint":102,"geoPoint":106,"contacts":107},"Children's Hospital of Orange County","Orange","92868",{"type":44,"coordinates":103},[104,105],-117.85311,33.78779,{"lat":105,"lon":104},[108,112],{"name":109,"role":31,"phone":110,"phoneExt":11,"email":111},"Leonard Sender, MD","714-509-8636","lsender@uci.edu",{"name":109,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":114,"status":37,"city":115,"state":58,"zip":116,"country":41,"countryCode":42,"cosmosGeoPoint":117,"geoPoint":121,"contacts":122},"University of California-San Francisco","San Francisco","94143",{"type":44,"coordinates":118},[119,120],-122.41942,37.77493,{"lat":120,"lon":119},[123,127],{"name":124,"role":31,"phone":125,"phoneExt":11,"email":126},"Robert Goldsby, MD","415-476-3831","goldsbyr@peds.ucsf.edu",{"name":124,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":129,"status":37,"city":130,"state":58,"zip":131,"country":41,"countryCode":42,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Stanford University School of Medicine","Stanford","94305",{"type":44,"coordinates":133},[134,135],-122.16608,37.42411,{"lat":135,"lon":134},[138,142],{"name":139,"role":31,"phone":140,"phoneExt":11,"email":141},"Sheri Spunt, MD","650-723-5535","sspunt@stanford.edu",{"name":139,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":144,"status":37,"city":145,"state":146,"zip":147,"country":41,"countryCode":42,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"Children's Hospital Colorado","Aurora","Colorado","80045",{"type":44,"coordinates":149},[150,151],-104.83192,39.72943,{"lat":151,"lon":150},[154,158],{"name":155,"role":31,"phone":156,"phoneExt":11,"email":157},"Brian Greffe, MD","720-777-6787","greffe.brian@tchden.org",{"name":159,"role":28,"phone":11,"phoneExt":11,"email":11},"Robert Greffe, MD",{"facility":161,"status":37,"city":162,"state":163,"zip":164,"country":41,"countryCode":42,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Children's National Medical Center","Washington D.C.","District of Columbia","20010",{"type":44,"coordinates":166},[167,168],-77.03637,38.89511,{"lat":168,"lon":167},[171,175],{"name":172,"role":31,"phone":173,"phoneExt":11,"email":174},"Jennifer Dean, MD","703-531-3627","jdean@psvcare.org",{"name":172,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":177,"status":37,"city":178,"state":179,"zip":180,"country":41,"countryCode":42,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Emory University\u002FChildren's Health Care of Atlanta","Atlanta","Georgia","30322",{"type":44,"coordinates":182},[183,184],-84.38798,33.749,{"lat":184,"lon":183},[187,191],{"name":188,"role":31,"phone":189,"phoneExt":11,"email":190},"Lillian Meacham, MD","404-727-0480","lillian.meacham@oz.ped.emory.edu",{"name":188,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":193,"status":37,"city":194,"state":195,"zip":196,"country":41,"countryCode":42,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Ana & Robert H. Lurie Children's Hospital of Chicago","Chicago","Illinois","60611-2605",{"type":44,"coordinates":198},[199,200],-87.65005,41.85003,{"lat":200,"lon":199},[203,207],{"name":204,"role":31,"phone":205,"phoneExt":11,"email":206},"Jennifer Reichek, MD, MSW","312-227-4777","jreichek@luriechildrens.org",{"name":204,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":209,"status":37,"city":194,"state":195,"zip":210,"country":41,"countryCode":42,"cosmosGeoPoint":211,"geoPoint":213,"contacts":214},"University of Chicago","60637",{"type":44,"coordinates":212},[199,200],{"lat":200,"lon":199},[215,218],{"name":216,"role":31,"phone":217,"phoneExt":11,"email":11},"Tara Henderson, MD, MPH","773-702-2501",{"name":216,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":220,"status":37,"city":221,"state":222,"zip":223,"country":41,"countryCode":42,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Indiana University\u002FRiley Hospital for Children","Indianapolis","Indiana","46202",{"type":44,"coordinates":225},[226,227],-86.15804,39.76838,{"lat":227,"lon":226},[230,234],{"name":231,"role":31,"phone":232,"phoneExt":11,"email":233},"Terry Vik, MD","317-944-8784","tvik@iupui.edu",{"name":231,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":236,"status":37,"city":237,"state":238,"zip":239,"country":41,"countryCode":42,"cosmosGeoPoint":240,"geoPoint":244,"contacts":245},"Dana-Farber Cancer Institute","Boston","Massachusetts","02215",{"type":44,"coordinates":241},[242,243],-71.05977,42.35843,{"lat":243,"lon":242},[246,250],{"name":247,"role":31,"phone":248,"phoneExt":11,"email":249},"Lisa Diller, MD","617-632-5642","lisa_diller@dfci.harvard.efu",{"name":247,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":252,"status":37,"city":253,"state":254,"zip":255,"country":41,"countryCode":42,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"University of Michigan\u002FMott Children's Hospital","Ann Arbor","Michigan","48109",{"type":44,"coordinates":257},[258,259],-83.74088,42.27756,{"lat":259,"lon":258},[262,266],{"name":263,"role":31,"phone":264,"phoneExt":11,"email":265},"Raymond Hutchinson, MD","734-764-7126","rhutchin@umich.edu",{"name":263,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":268,"status":37,"city":269,"state":270,"zip":271,"country":41,"countryCode":42,"cosmosGeoPoint":272,"geoPoint":276,"contacts":277},"Children's Hospitals & Clinics of Minnesota","Minneapolis","Minnesota","55404",{"type":44,"coordinates":273},[274,275],-93.26384,44.97997,{"lat":275,"lon":274},[278,282],{"name":279,"role":31,"phone":280,"phoneExt":11,"email":281},"Katharine R. Lange, MD","612-813-6560","Katharine.Lange@childrensmn.org",{"name":279,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":284,"status":285,"city":269,"state":270,"zip":286,"country":41,"countryCode":42,"cosmosGeoPoint":287,"geoPoint":289,"contacts":11},"University of Minnesota","COMPLETED","55455",{"type":44,"coordinates":288},[274,275],{"lat":275,"lon":274},{"facility":291,"status":285,"city":292,"state":270,"zip":293,"country":41,"countryCode":42,"cosmosGeoPoint":294,"geoPoint":298,"contacts":11},"Mayo Clinic","Rochester","55905",{"type":44,"coordinates":295},[296,297],-92.4699,44.02163,{"lat":297,"lon":296},{"facility":300,"status":37,"city":301,"state":302,"zip":303,"country":41,"countryCode":42,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"St. Louis Children's Hospital\u002FThe Washington University","St Louis","Missouri","63130",{"type":44,"coordinates":305},[306,307],-90.19789,38.62727,{"lat":307,"lon":306},[310,314],{"name":311,"role":31,"phone":312,"phoneExt":11,"email":313},"Robert Hayashi, PhD","314-454-4118","hayashi_r@kids.wustl.edu",{"name":315,"role":28,"phone":11,"phoneExt":11,"email":11},"Mark Hayashi, PhD",{"facility":317,"status":37,"city":318,"state":319,"zip":320,"country":41,"countryCode":42,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"Roswell Park Cancer Institute","Buffalo","New York","14263",{"type":44,"coordinates":322},[323,324],-78.87837,42.88645,{"lat":324,"lon":323},[327,331],{"name":328,"role":31,"phone":329,"phoneExt":11,"email":330},"Denise Rokitka, MD","716-845-2333","denise.rokitka@roswellpark.org",{"name":328,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":333,"status":37,"city":319,"state":319,"zip":334,"country":41,"countryCode":42,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"Memorial-Sloan Kettering Cancer Center","10065",{"type":44,"coordinates":336},[337,338],-74.00597,40.71427,{"lat":338,"lon":337},[341,345],{"name":342,"role":31,"phone":343,"phoneExt":11,"email":344},"Danielle Friedman, MD","212-639-8138","friedmad@mskcc.org",{"name":342,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":347,"status":37,"city":348,"state":349,"zip":350,"country":41,"countryCode":42,"cosmosGeoPoint":351,"geoPoint":355,"contacts":356},"Nationwide Children's Hospital","Columbus","Ohio","43205",{"type":44,"coordinates":352},[353,354],-82.99879,39.96118,{"lat":354,"lon":353},[357,361],{"name":358,"role":31,"phone":359,"phoneExt":11,"email":360},"Randy Olshefski","614-722-3553","randal.olshefski@nationwidechildrens.org",{"name":362,"role":28,"phone":11,"phoneExt":11,"email":11},"Randy Olshefki",{"facility":364,"status":37,"city":365,"state":366,"zip":367,"country":41,"countryCode":42,"cosmosGeoPoint":368,"geoPoint":372,"contacts":373},"Children's Hospital of Philadelphia","Philadelphia","Pennsylvania","19104",{"type":44,"coordinates":369},[370,371],-75.16362,39.95238,{"lat":371,"lon":370},[374,378],{"name":375,"role":31,"phone":376,"phoneExt":11,"email":377},"Jill Ginsberg, MD","215-590-7399","ginsbergji@email.chop.edu",{"name":375,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":380,"status":37,"city":381,"state":366,"zip":382,"country":41,"countryCode":42,"cosmosGeoPoint":383,"geoPoint":387,"contacts":388},"Children's Hospital of Pittsburgh","Pittsburgh","15213",{"type":44,"coordinates":384},[385,386],-79.99589,40.44062,{"lat":386,"lon":385},[389,393],{"name":390,"role":31,"phone":391,"phoneExt":11,"email":392},"Jean Tersak, MD","412-692-5963","jean.tersak@chp.edu",{"name":390,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":5,"status":37,"city":395,"state":396,"zip":397,"country":41,"countryCode":42,"cosmosGeoPoint":398,"geoPoint":402,"contacts":403},"Memphis","Tennessee","38105",{"type":44,"coordinates":399},[400,401],-90.04898,35.14953,{"lat":401,"lon":400},[404,406],{"name":27,"role":31,"phone":32,"phoneExt":11,"email":405},"ccss@stjude.org",{"name":27,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":408,"status":285,"city":409,"state":410,"zip":411,"country":41,"countryCode":42,"cosmosGeoPoint":412,"geoPoint":416,"contacts":11},"University of Texas Southwestern Medical Center","Dallas","Texas","75390",{"type":44,"coordinates":413},[414,415],-96.80667,32.78306,{"lat":415,"lon":414},{"facility":418,"status":37,"city":419,"state":410,"zip":420,"country":41,"countryCode":42,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"Cook Children's Medical Center","Fort Worth","76104",{"type":44,"coordinates":422},[423,424],-97.32085,32.72541,{"lat":424,"lon":423},[427,431],{"name":428,"role":31,"phone":429,"phoneExt":11,"email":430},"Donald Beam, MD","682-885-4007","donald.beam@cookchildrens.org",{"name":428,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":433,"status":37,"city":434,"state":410,"zip":435,"country":41,"countryCode":42,"cosmosGeoPoint":436,"geoPoint":440,"contacts":441},"M.D. Anderson Cancer Center","Houston","77030",{"type":44,"coordinates":437},[438,439],-95.36327,29.76328,{"lat":439,"lon":438},[442,446],{"name":443,"role":31,"phone":444,"phoneExt":11,"email":445},"Louise Strong, MD","713-792-2589","lstrong@mdanderson.org",{"name":443,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":448,"status":37,"city":434,"state":410,"zip":435,"country":41,"countryCode":42,"cosmosGeoPoint":449,"geoPoint":451,"contacts":452},"Texas Children's Hospital",{"type":44,"coordinates":450},[438,439],{"lat":439,"lon":438},[453,457],{"name":454,"role":31,"phone":455,"phoneExt":11,"email":456},"ZoAnn E. Dreyer, MD","832-822-4209","zdreyer@bcm.edu",{"name":454,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":459,"status":37,"city":460,"state":461,"zip":462,"country":41,"countryCode":42,"cosmosGeoPoint":463,"geoPoint":467,"contacts":468},"Seattle Children's Hospital","Seattle","Washington","98105",{"type":44,"coordinates":464},[465,466],-122.33207,47.60621,{"lat":466,"lon":465},[469,473],{"name":470,"role":31,"phone":471,"phoneExt":11,"email":472},"Scott Baker, MD","206-884-1018","ksbaker@fhcrc.org",{"name":470,"role":28,"phone":11,"phoneExt":11,"email":11},{"facility":475,"status":37,"city":476,"state":477,"zip":478,"country":479,"countryCode":480,"cosmosGeoPoint":481,"geoPoint":485,"contacts":486},"The Hospital for Sick Children","Toronto","Ontario","M5G-1XB","Canada","CA",{"type":44,"coordinates":482},[483,484],-79.39864,43.70643,{"lat":484,"lon":483},[487,491],{"name":488,"role":31,"phone":489,"phoneExt":11,"email":490},"Paul Nathan, MD","416-813-8795","paul.nathan@sickkids.ca",{"name":488,"role":28,"phone":11,"phoneExt":11,"email":11},{"type":493,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[495,498,500,501,502,504,506],{"name":496,"class":497},"National Cancer Institute (NCI)","NIH",{"name":499,"class":6},"Fred Hutchinson Cancer Center",{"name":347,"class":6},{"name":433,"class":6},{"name":503,"class":6},"University of Southern California",{"name":505,"class":6},"Children's Hospital Medical Center, Cincinnati",{"name":507,"class":6},"University of California, San Francisco","100142079",false,"NCT01120353","Childhood Cancer Survivor Study","Inclusion Criteria:\n\nInitial Cohort:\n\n* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.\n\nExpanded cohort:\n\n* Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.\n* English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.\n\nExclusion Criteria:\n\n* Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and\u002For chemotherapy.\n* Non-English speaking or residence outside the US or Canada.\n\nSibling Controls:\n\n* For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.",true,"ALL",{"count":516,"type":517},50000,"ESTIMATED","OBSERVATIONAL","The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and\u002For surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.",[521],"Cancer",[523,524,525],"Childhood cancer","Young Children","Adults","2026-06-15",{"date":528,"type":529},"2026-06-17","ACTUAL",{"date":531,"type":529},"1995-01-05",{"date":533,"type":517},"2026-11",{"name":5,"class":6},31]