[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100430461":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":30,"studyPopulation":31,"armGroups":32,"interventions":27,"overallOfficials":36,"centralContacts":40,"locations":45,"responsibleParty":61,"collaborators":27,"id":64,"slug":27,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":27,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":27,"briefSummary":77,"conditions":78,"keywords":27,"overallStatus":48,"whyStopped":27,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Dongzhimen Hospital, Beijing","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"Effective Survival","The time from disease onset to death, tracheostomy, or permanent assisted ventilation","Through study completion, an average of 3 months",[14,17,20,24],{"measure":15,"description":16,"timeFrame":12},"Overall Survival","Death owing to any causes",{"measure":18,"description":19,"timeFrame":12},"Rate of Disease Progression","(48-total ALSFRS-R)\u002Fsymptom duration (months)",{"measure":21,"description":22,"timeFrame":23},"Rate of Forced Vital Capacity (FVC) Decline","The slope of decline of forced vital capacity (FVC) to assess the respiratory function.","through study completion, an average of 3 months",{"measure":25,"description":26,"timeFrame":12},"Rate of Body Mass Index (BMI) Decline","The slope of decline of body mass index (BMI) to assess the disease progression.",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":6,"timePerspective":29,"maskingInfo":27},"PROSPECTIVE","The CARE-TCM is a prospective, multi-center, patient registry study. Eligible ALS patients with TCM treatments will be enrolled in the registry. After enrollment, this research collects the individual characteristics of patients' status. Longitudinal follow-up data are collected from both patients (primary caregivers) and their treating neurologists every 3 months for 5 years. The aims of the CARE-TCM are to: 1) explore the general characteristics of ALS patients with TCM and; 2) assess the effectiveness and safety of various TCMs on ALS based on nationwide registry outcome collecting process.","Patients who meet the criteria will be enrolled from multi-centers in China.",[33],{"label":34,"type":27,"description":35,"interventionNames":27},"Amyotrophic lateral sclerosis patients","Amyotrophic lateral sclerosis patients with traditional Chinese medicine",[37],{"name":38,"affiliation":5,"role":39},"Ying Gao, MD, PhD","PRINCIPAL_INVESTIGATOR",[41],{"name":38,"role":42,"phone":43,"phoneExt":27,"email":44},"CONTACT","+86-10-84013209","gaoying973@126.com",[46],{"facility":47,"status":48,"city":49,"state":27,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Dongzhimen Hospital, Beijing University of Chinese Medicine","RECRUITING","Beijing","100700","China","CN",{"type":54,"coordinates":55},"Point",[56,57],116.39723,39.9075,{"lat":57,"lon":56},[60],{"name":38,"role":42,"phone":43,"phoneExt":27,"email":44},{"type":39,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"Ying Gao","MD, PhD, Professor","100430461",false,"NCT04885374","China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine","CARE-TCM","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients with possible, laboratory supported probable, probable, or definite ALS according to the revised El Escorial criteria.\n* ALS patients treated with traditional Chinese medicine.\n\nExclusion Criteria:\n\n* Patients who refuse informed consent.","ALL","18 Years",{"count":73,"type":74},2000,"ESTIMATED","5 Years","OBSERVATIONAL","A multi-center registration study of clinical characteristics of amyotrophic lateral sclerosis (ALS) patients with traditional Chinese medicine (TCM).",[79],"Amyotrophic Lateral Sclerosis","2021-05-08",{"date":82,"type":83},"2021-05-13","ACTUAL",{"date":85,"type":83},"2021-03-01",{"date":87,"type":74},"2028-03-01",{"name":5,"class":6},1]