[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630965":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":13,"locations":19,"responsibleParty":43,"collaborators":47,"id":65,"slug":10,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":85,"overallStatus":89,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Chinese PLA General Hospital","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Sub-cohort 1 - Elderly Adults without chronic kidney disease (CKD) at Baseline",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Sub-cohort 2 - Elderly Patients with chronic kidney disease (CKD)",[14],{"name":15,"role":16,"phone":17,"phoneExt":10,"email":18},"Shuang Liang","CONTACT","86+15110246423","liangshuang301@163.com",[20,31],{"facility":5,"status":10,"city":21,"state":22,"zip":23,"country":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":10},"Beijing","Beijing Municipality","100853","China",{"type":26,"coordinates":27},"Point",[28,29],116.39723,39.9075,{"lat":29,"lon":28},{"facility":32,"status":10,"city":21,"state":22,"zip":23,"country":24,"cosmosGeoPoint":33,"geoPoint":35,"contacts":36},"chinese PLA general hospital",{"type":26,"coordinates":34},[28,29],{"lat":29,"lon":28},[37,39],{"name":38,"role":16,"phone":17,"phoneExt":10,"email":18},"Shuang Liang, PhD",{"name":40,"role":16,"phone":41,"phoneExt":10,"email":42},"Yisha Li, PhD","86+18911772124","xiaoyixueda@qq.com",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Yuanjun Yang","Principal Investigator",[48,50,52,54,56,58,61,63],{"name":49,"class":6},"Fudan University",{"name":51,"class":6},"Beijing Chao Yang Hospital",{"name":53,"class":6},"The First Affiliated Hospital of Dalian Medical University",{"name":55,"class":6},"Beijing Luhe Hospital",{"name":57,"class":6},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"name":59,"class":60},"Shandong Provincial Hospital","OTHER_GOV",{"name":62,"class":6},"Second Xiangya Hospital of Central South University",{"name":64,"class":6},"Tianjin Medical University","100630965",false,"NCT07494526","Chronic Kidney Disease and Metabolic Disorders in the Elderly","Research on the Prevention, Control, and Intelligent Management Decision-Making for Comorbidities of Chronic Kidney Disease and Metabolic Disorders in the Elderly","For Sub-cohort 1, the inclusion and exclusion criteria are as follows:\n\nInclusion Criteria:\n\n1. Baseline age ≥ 65 years.\n2. Availability of baseline data on serum creatinine and at least one urinary protein measurement.\n3. Urinary protein measurements include: UACR, UPCR, 24-hour urine protein quantification, and urine protein dipstick test.\n4. Baseline date requirement: Between January 1, 2010, and December 31, 2025.\n5. Follow-up requirement meeting at least one of the following: At least one serum creatinine measurement with an interval of ≥ 6 months after baseline. Occurrence of a primary endpoint event (new-onset CKD).\n\nExclusion Criteria:\n\nPresence of CKD at baseline, defined as: Glomerular filtration rate (eGFR) \\\u003C 60 ml\u002F(min·1.73m²) or positive urine protein; or the presence of an ICD-10 diagnostic code for CKD in medical records.\n\nFor Sub-cohort 2 (CKD Patients), the inclusion and exclusion criteria are as follows:\n\nInclusion Criteria:\n\n1. Baseline age ≥ 65 years.\n2. Meeting the diagnostic criteria for CKD: Glomerular filtration rate (eGFR) \\\u003C 60 ml\u002F(min·1.73m²) or urine protein (UACR ≥ 30 mg\u002Fg); or based on ICD-10 codes.\n3. Baseline date requirement: Between January 1, 2010, and December 31, 2025.\n4. Follow-up requirement meeting at least one of the following:\n\nOccurrence of a primary endpoint event (mortality, ESRD); At least one serum creatinine measurement with an interval of ≥ 6 months after baseline.\n\nExclusion Criteria:\n\n1. End-stage renal disease (ESRD) at baseline (eGFR \\\u003C 15 ml\u002F(min·1.73m²), or prior receipt of kidney transplant or dialysis), based on ICD codes).\n2. Diagnosis of acute kidney injury (AKI) within the preceding 3 months.\n3. New York Heart Association (NYHA) Class III or IV heart failure or occurrence of acute myocardial infarction within the preceding 6 months.\n4. Child-Pugh Class B or C liver cirrhosis.\n5. Malignant neoplasm.",true,"ALL","65 Years",{"count":75,"type":76},100000,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney disease (CKD) at baseline, and one comprising elderly patients with established CKD.\n\nThe main questions it aims to answer are:\n\nDo metabolic diseases (diabetes, hypertension, hyperlipidemia, hyperuricemia, calcium-phosphorus disorders) increase the risk of incident CKD, major adverse cardiovascular events (MACE), and all-cause mortality in elderly individuals without CKD at baseline? What are the optimal diagnostic thresholds and criteria for CKD in the elderly population? How do metabolic comorbidities affect long-term outcomes - including all-cause mortality, end-stage renal disease (ESRD), and cardiovascular events - in elderly patients with established CKD? What is the comorbidity profile and disease burden of elderly CKD patients in China?\n\nParticipants in both sub-cohorts will:\n\nUndergo baseline assessments including laboratory tests and clinical evaluations.\n\nProvide longitudinal follow-up data through scheduled clinic visits and medical record linkage.\n\nContribute to a large-scale cohort of 100,000 elderly participants across multiple centers in China.",[80,81,82,83,84],"Chronic Kidney Diease","Diabetes Mellitus","Hypertension","Hyperlipidemia","Hyperuricemia",[86,87,88],"chronic kidney disease","elderly","metabolic disorders","NOT_YET_RECRUITING","2026-03-20",{"date":92,"type":93},"2026-03-27","ACTUAL",{"date":95,"type":76},"2026-04",{"date":97,"type":76},"2028-12",{"name":5,"class":6},2]