[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640721":3},{"organization":4,"outcomesModule":7,"designInfo":28,"detailedDescription":27,"studyPopulation":31,"armGroups":32,"interventions":46,"overallOfficials":51,"centralContacts":56,"locations":65,"responsibleParty":84,"collaborators":27,"id":86,"slug":27,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":27,"maxAge":93,"enrollmentInfo":94,"targetDuration":27,"studyType":97,"phases":27,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":106,"whyStopped":27,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Institut Cancerologie de l'Ouest","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":27},[9],{"measure":10,"description":11,"timeFrame":12},"event-free survival","event-free survival (time between diagnosis and the occurrence of the first event among the following: local recurrence, metastatic recurrence, death)","up to 5 years",[14,17,21,24],{"measure":15,"description":16,"timeFrame":12},"Describe the association between age at diagnosis and event-free survival (EFS) and overall survival.","Describe the association between age at diagnosis and event-free survival (EFS) and overall survival (time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data)",{"measure":18,"description":19,"timeFrame":20},"Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years).","Describe the association between previous pregnancy and overall survival according to age at diagnosis (≤45 years or ≥55 years). (Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data)","Up to 5 years",{"measure":22,"description":23,"timeFrame":20},"Describe the association between breastfeeding and EFS\u002Foverall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years).","Describe the association between breastfeeding and EFS\u002Foverall survival in nulliparous women according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data)",{"measure":25,"description":26,"timeFrame":20},"Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS\u002Foverall survival according to age at diagnosis (≤45 years or ≥55 years).","Describe the association between age at first pregnancy (≥35 years, ≤35 years, nulliparity) and EFS\u002Foverall survival according to age at diagnosis (≤45 years or ≥55 years).(Overall survival: time between diagnosis and death from all causes. Two overall survival rates will be calculated from two data sources: ICO data and INSEE data)",null,{"allocation":27,"interventionModel":27,"interventionModelDescription":27,"primaryPurpose":27,"observationalModel":29,"timePerspective":30,"maskingInfo":27},"COHORT","RETROSPECTIVE","Patients with triple-negative (TN) or RH+ breast cancer treated at the ICO who were ≤ 45 years old or ≥ 55 years old at the time of diagnosis.",[33,37,40,43],{"label":34,"type":27,"description":27,"interventionNames":35},"Patient aged ≤ 45 years at diagnosis Triple-negative breast cancer",[36],"Other: No Intervention: Observational Cohort",{"label":38,"type":27,"description":27,"interventionNames":39},"Patient aged ≤ 45 years at diagnosis RH+ breast cancer",[36],{"label":41,"type":27,"description":27,"interventionNames":42},"Patient aged ≥ 55 years at diagnosis Triple-negative breast cancer",[36],{"label":44,"type":27,"description":27,"interventionNames":45},"Patient aged ≥ 55 years at diagnosis RH+ breast cancer",[36],[47],{"type":6,"name":48,"description":49,"armGroupLabels":50,"otherNames":27},"No Intervention: Observational Cohort","No intervention",[38,34,44,41],[52],{"name":53,"affiliation":54,"role":55},"Marie ROBERT, MD","INSTITUT DE CANCEROLOGIE DE L'OUEST","PRINCIPAL_INVESTIGATOR",[57,61],{"name":53,"role":58,"phone":59,"phoneExt":27,"email":60},"CONTACT","+33240679900","marie.robert@ico.unicancer.fr",{"name":62,"role":58,"phone":63,"phoneExt":27,"email":64},"Vincent GUEN, Ph D","+ 33 2 28 08 02 89","Vincent.Guen@univ-nantes.fr",[66],{"facility":67,"status":27,"city":68,"state":27,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"Institut de Cancerologie de L'Ouest","Saint-Herblain","44800","France","FR",{"type":73,"coordinates":74},"Point",[75,76],-1.651,47.21154,{"lat":76,"lon":75},[79,83],{"name":80,"role":58,"phone":81,"phoneExt":27,"email":82},"Laetitia HIMPE","+33240679747","laetitia.himpe@ico.unicancer.fr",{"name":53,"role":55,"phone":27,"phoneExt":27,"email":27},{"type":85,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100640721",false,"NCT07601152","Clinical and Biological Study of Early-onset Breast Cancer and the Influence of the Reproductive Cycle on the Aggressiveness of the Disease","ARTEMIS","Inclusion Criteria:\n\n* Triple-negative breast cancer or RH+\u002FHER2-\n* Patient aged ≤ 45 years at the time of diagnosis ou Patient aged ≥ 55 years at the time of diagnosis\n\nExclusion Criteria:\n\n* Availability of a diagnostic tumor sample","FEMALE","45 Years",{"count":95,"type":96},1000,"ESTIMATED","OBSERVATIONAL","The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood.\n\nAmong young patients, some are nulliparous and others have reported cancer during or after pregnancy. Preliminary studies suggest that breast tissue remodeling associated with pregnancy may influence the emergence and aggressiveness of early-onset cancers. However, breastfeeding and pregnancy are described as protective factors against the onset of breast cancer. The precise biology depending on age and the time between pregnancy and breast cancer is still poorly understood.\n\nThe aim of our study is to increase our knowledge of cancer in young women and its potential links to pregnancy and breastfeeding. Information on the contraceptive habits and pregnancies of the patients in the study will be collected, and molecular and cellular analyses will be performed on frozen tumor samples as well as samples fixed and embedded in paraffin.",[100],"Breast Cancer",[102,103,104,105],"Early breast cancer","breastfeeding","pregnancy","reproductive cycle","NOT_YET_RECRUITING","2026-05-20",{"date":109,"type":110},"2026-05-22","ACTUAL",{"date":112,"type":96},"2026-05",{"date":114,"type":96},"2031-02",{"name":5,"class":6},1]