Clinical Study of Super Transplantation in the Treatment of Severe β-thalassemia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-10
SponsorGuangzhou Women and Children's Medical Center
About this trial
This is a single-arm, open label, phase 1 study in subjects with beta-thalassemia. This study will evaluate the safety and efficacy of preconditioning-free super-transplantation on beta-thalassemia pediatric patients.
Eligibility criteria
Qualifiers
Diagnosis of severe β -thalassemia
Age between 7-10 years old, male and female; Weight < 40kg
The patient has or does not have an HLA-compatible or semi-compatible donor, but unconditional transplantation or refusal of blood stem cell transplantation; Patients with thalassemia gene therapy without conditions or refusal;
There are fully compatible or incompatible HLA donors, and the physical examination meets the donor conditions;
Disqualifiers
Mental patients;
Participants in other drug clinical trials within the past 1 month;
There are no suitable HLA-incompatible donors.
Other researchers decide that it is not suitable to participate in this researcher.
Trial design
Treatments tested in this trial
- super-transplantation in 3 severe β -thalassemia pediatric patients.
Treatment groups
3 Participants
are divided into 1 treatment groupLocations
2Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University51000, GuangzhouGuangdong, China
Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University GuangzhouGuangdong, China
Sponsors and collaborators
Guangzhou Women and Children's Medical Center
Lead sponsor
Source ClinicalTrials.gov