This project aims to evaluate the efficacy and safety of oral taurine supplementation combined with PD-1 inhibitor (serplulimab) and chemotherapy in inducing systemic CD8+ T cell responses and achieving improved gastric cancer patient outcomes than with serplulimab and chemotherapy alone.
Age 18-75 years old, no gender limitation;
Pathologically confirmed gastric or gastroesophageal junction adenocarcinoma with cTNM stage II/III，T≥3, N ≥0, M=0；
Expected survival of ≥ 3 months;
The tumor specimens were PD-L1 positive (CPS ≥ 1)；
Use of taurine agent within 1 month prior to the first dose of study treatment and throughout the study;
Patients with positive HER-2；
Patients with gastrointestinal obstruction or active bleeding in the gastrointestinal tract, as well as perforation and dysphagia;
Patients with severe heart, lung, liver, kidney, endocrine, hematopoietic system or psychiatric diseases were considered not suitable for the study group;
Tang-Du Hospital
Lead sponsor