To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
patient with eye which has limbal stem cell deficiency and conjunctivalization of cornea
patient who shows no improvement after limbal tissue or amniotic membrane transplantation, or who has difficulty in receiving long-term immunosuppressive treatment
patient who agree this clinical trial
patient with the eyes in which best corrected visual acuity is less than counting finger
patient who has relevant corneal transparency
patient who is on the pregnancy or has a plan of pregnancy within 1 year
patient who has corneal infection
patient who has diagnosis of HBV, HCV, HIV, syphilis
Seoul National University Hospital
Lead sponsor
Ministry of Health & Welfare, Korea
Collaborator