About this trial

The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise training groups, decreases stress, improves mood, increases physical activity and physical fitness, and decreases insulin resistance among teenagers at risk for diabetes.

Eligibility criteria

Qualifiers

Female

Age 12-17 years

Body Mass Index (BMI)>= 85 for age and sex

Type 2 Diabetes (T2D) first-or second-degree relative

Disqualifiers

T2D/ Type 1 Diabetes (T1D) or any major medical condition (e.g. cardiovascular, renal) that would prohibit the ability to participate in exercise training

Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) conduct disorder, substance abuse/ dependence, obsessive compulsive disorder, panic attacks, post-traumatic stress disorder, anorexia/bulimia, & schizophrenia

Insulin sensitizers, weight loss medications & chronic steroids

Structured weight loss treatment or bariatric surgery

Trial design

Treatments tested in this trial

  • Cognitive-Behavioral Therapy followed by Exercise Training
  • Exercise Training followed by Cognitive-Behavioral Therapy
  • Cognitive-Behavioral Therapy Only
  • Exercise Training Only

Treatment groups

300 Participants
are divided into 4 treatment groups

Locations

2
Children's Hospital Colorado80011, AuroraColorado, United States
Colorado State University80523, Fort CollinsColorado, United States

Sponsors and collaborators

Colorado State University

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

University of Colorado, Denver

Collaborator