[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100270533":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":40,"collaborators":7,"id":43,"slug":7,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":44,"sex":50,"minAge":51,"maxAge":7,"enrollmentInfo":52,"targetDuration":7,"studyType":55,"phases":7,"briefSummary":56,"conditions":57,"keywords":7,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Groupe Hospitalier Diaconesses Croix Saint-Simon","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"VALERIE ZELLER, Doctorate","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"YOUNES KERROUMI, Doctorate","CONTACT","(+33) 1 64 44 33 84","ykerroumi@hopital-dcss.org",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Groupe Hospitalier Diaconesses Croix Saint Simon","RECRUITING","Paris","Île-de-France Region","75020","France",{"type":27,"coordinates":28},"Point",[29,30],2.3488,48.85341,{"lat":30,"lon":29},[33,36],{"name":34,"role":15,"phone":35,"phoneExt":7,"email":17},"Younes KERROUMI, Doctorate","(+33)1 44 64 33 84",{"name":37,"role":15,"phone":38,"phoneExt":7,"email":39},"Valérie ZELLER, Doctorate","(+33)1 44 64 17 80","vzeller@hopital-dcss.org",{"type":11,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Dr Valerie ZELLER","infectious diseases specialist","100270533",false,"NCT02801253","Cohort of Prosthetic Joint Infections","Prospective Cohort of Patients With Prosthetic Joint Infection","COPINS","Inclusion Criteria:\n\n* Patient aged over 18 years old with hip, knee and or shoulder joint prosthesis who consented to participate in the study with:\n* According to musculoskeletal infection society definition: PJI is present when one of the major criteria exists or four out of six minor criteria.\n\nMajor Criteria:\n\n* Two positive periprosthetic cultures with phenotypically identical organisms, OR\n* A sinus tract communicating with the joint, OR\n\nMinor Criteria:\n\n* Elevated serum C-reactive protein (CRP) AND erythrocyte sedimentation rate (ESR)\n* Elevated synovial fluid white blood cell (WBC)\n* Elevated synovial fluid polymorphonuclear neutrophil percentage (PMN%)\n* The presence of pus in the joint without known cause\n* Positive histological analysis of periprosthetic tissue\n* A single positive culture\n\nOr a PJI which meets the following three criteria:\n\n* Medical story suggesting prosthetic joint infection.\n* The presence of pain either with or without swelling for more than 3 months unrelated to a mechanical cause.\n* Germ identification in a single sample of fluid aspiration or tissue culture.\n\n  * Or microbial growth in prosthesis sonication fluid culture greater than 50CFU\u002Fml.\n\nExclusion Criteria:\n\n* Patient who does not meet eligibility criteria.\n* Patient lawfully deprived of his liberty.\n* Patient not insured under social security scheme.","ALL","18 Years",{"count":53,"type":54},800,"ESTIMATED","OBSERVATIONAL","Management of prosthetic joint infections (PJI) is a challenging task. These infections include different clinical and microbiological settings calling upon various treatment strategies according to infection type (acute or chronic), bone quality, the involved micro-organism and the patient's general condition and willing.\n\nTreatment of PJI combines surgery and prolonged antibiotic therapy. In some patients with a high operative risk prolonged suppressive antibiotic therapy can be used.\n\nLack of large prospective studies motivated the conception of this cohort with a long term follow up, regardless to PJI management procedures.",[58],"Prosthetic Joint Infection","2022-03-28",{"date":61,"type":62},"2022-03-29","ACTUAL",{"date":64,"type":62},"2015-09-11",{"date":66,"type":54},"2029-09",{"name":5,"class":6},1]