[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636465":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":33,"responsibleParty":70,"collaborators":72,"id":75,"slug":18,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":18,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":18,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":99,"whyStopped":18,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of Colorado, Denver","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PPP Injection Treated Arm","EXPERIMENTAL","US-guided aspiration of hematoma (if present) and injection of small volume (1-6cc's) of autologous platelet poor plasma (PPP) at the site of injury and post-injection physical therapy.",[13],"Device: Platelet Poor Plasma (PPP) Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"No Injection Arm","NO_INTERVENTION","Standard of care pathway with US-guided aspiration of hematoma (if present) and physical therapy only.",null,[20],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":18},"DEVICE","Platelet Poor Plasma (PPP) Injection",[9],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Jason L Dragoo, MD","CONTACT","303-724-1055","J.DRAGOO@CUANSCHUTZ.EDU",{"name":31,"role":27,"phone":18,"phoneExt":18,"email":32},"Inverness Clinical Trials","Inverness.clinicaltrials@cuanschutz.edu",[34,50,60],{"facility":35,"status":18,"city":36,"state":37,"zip":38,"country":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Colorado | Steadman Hawkins Clinic Denver","Englewood","Colorado","80112","United States",{"type":41,"coordinates":42},"Point",[43,44],-104.98776,39.64777,{"lat":44,"lon":43},[47,49],{"name":26,"role":27,"phone":48,"phoneExt":18,"email":29},"720-872-4836",{"name":31,"role":27,"phone":48,"phoneExt":18,"email":32},{"facility":51,"status":18,"city":52,"state":53,"zip":54,"country":39,"cosmosGeoPoint":55,"geoPoint":59,"contacts":18},"Emory University","Atlanta","Georgia","30322",{"type":41,"coordinates":56},[57,58],-84.38798,33.749,{"lat":58,"lon":57},{"facility":61,"status":18,"city":62,"state":63,"zip":64,"country":39,"cosmosGeoPoint":65,"geoPoint":69,"contacts":18},"University of Iowa","Iowa City","Iowa","52242",{"type":41,"coordinates":66},[67,68],-91.53017,41.66113,{"lat":68,"lon":67},{"type":71,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[73,74],{"name":51,"class":6},{"name":61,"class":6},"100636465",false,"NCT07566039","Cohort Study of PPP Injections for Athletes With Muscle Injury","Prospective Cohort Study of Athletes Following an Injection of Platelet-Poor Plasma Into an Acute Muscle Injury","Inclusion Criteria:\n\n* Age between 18 and 45 years\n* Diagnosis of a muscle strain in the lower extremities, including but not limited to hamstring, quadriceps, and gastrocnemius\n* Injury occurred within 10 days of the initial clinical evaluation\n* Injury occurred while engaging in athletic or sporting activities\n* Participants must be willing to undergo prescribed physical therapy\n* Participants have agreed to standard-of-care management for their injury, which may include ultrasound-guided aspiration with or without a platelet-poor plasma injection\n\nExclusion Criteria:\n\n* Previous injection at the injury site.\n* Pregnant or breastfeeding women, or women who may become pregnant during the study duration\n* Injuries resulting from puncture or crush trauma\n* Injuries occurring more than 10 days prior to the injection date\n* Injuries not caused by athletic or sporting activity\n* Previous muscle injury in the same muscle group within 6 months","ALL","18 Years","45 Years",{"count":85,"type":86},90,"ESTIMATED","INTERVENTIONAL",[89],"NA","The investigators hypothesize that a single injection of platelet-poor plasma (PPP) into an acute muscle injury will significantly improve local muscle regeneration and patient outcomes compared to the standard of care using only ultrasound-guided hematoma aspiration. Muscle regeneration will be assessed through quantitative MRI analysis. The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six-month period.",[92],"Lower Extremity Injury",[94,95,96,97,98],"Lower extremity injury","PPP injection","Platelet Poor Plasma injection","Athlete","muscle injury","NOT_YET_RECRUITING","2026-05-04",{"date":102,"type":103},"2026-05-06","ACTUAL",{"date":105,"type":86},"2026-05-01",{"date":107,"type":86},"2030-12-31",{"name":5,"class":6},3]