[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631251":3},{"organization":4,"outcomesModule":7,"designInfo":18,"detailedDescription":21,"studyPopulation":22,"armGroups":23,"interventions":17,"overallOfficials":34,"centralContacts":38,"locations":48,"responsibleParty":66,"collaborators":68,"id":71,"slug":17,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":17,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":17,"enrollmentInfo":79,"targetDuration":17,"studyType":82,"phases":17,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":50,"whyStopped":17,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Medical University of Graz","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":17},[9],{"measure":10,"description":11,"timeFrame":12},"Analysis of collagen fragments","The fragments will be measured in the plasma, serum, or tissue using an enzyme-linked immunosorbent assay (ELISA), mass spectrometry, or single-cell analysis.","within 48 months",[14],{"measure":15,"description":16,"timeFrame":12},"Disease severity assessment","The assessment of disease severity will be based on the associated clinical data and compared to the generated collagen fingerprint, as determined by the primary outcome.",null,{"allocation":17,"interventionModel":17,"interventionModelDescription":17,"primaryPurpose":17,"observationalModel":19,"timePerspective":20,"maskingInfo":17},"COHORT","PROSPECTIVE","Pulmonary hypertension (PH) is a severe complication of chronic lung diseases (CLDs) that significantly worsens patient outcomes. Although extracellular matrix (ECM) remodeling is central to PH pathogenesis, the basement membrane (BM)-a specialized ECM-remains understudied. The BM's dynamic role in lung tissue organization and signaling may provide insight into disease progression and phenotypic heterogeneity.\n\nThe investigators hypothesize that BM remodeling and the release of its bioactive components generate a measurable molecular fingerprint reflecting PH onset and progression in CLD. This study aims to prove the concept of using BM-derived fingerprints for disease detection and patient stratification.","Patients undergoing lung transplantation with COPD or PF, with or without associated PH or PAH.\n\nOutpatient cohort with COPD or PF, with or without associated PH or PAH.",[24,27,29,31],{"label":25,"type":17,"description":26,"interventionNames":17},"Patients with confirmed COPD with or without pulmonary hypertension (COPD\u002FPH group)","Tissue Sampling Blood is collected via venipuncture into citrate- or ethylenediaminetetraacetic acid (EDTA)-containing Vacutainer tubes, as well as into serum tubes. Obtain explant lung tissue from patients who have undergone lung transplantation.",{"label":28,"type":17,"description":26,"interventionNames":17},"Patients with confirmed pulmonary fibrosis with or without pulmonary hypertension (PF\u002FPH group)",{"label":30,"type":17,"description":26,"interventionNames":17},"Patients with confirmed pulmonary arterial hypertension (PAH group)",{"label":32,"type":17,"description":33,"interventionNames":17},"Control group without diagnosed COPD, PF or pulmonary hypertension (Control group)","Tissue Sampling Blood is collected via venipuncture into citrate- or ethylenediaminetetraacetic acid (EDTA)-containing Vacutainer tubes, as well as into serum tubes. Explant lung tissue is obtained from patients who have undergone lung transplantation.\n\nNon-transplanted donor lungs that were harvested for transplantation but not implanted due to size reduction serve as controls.",[35],{"name":36,"affiliation":5,"role":37},"Nikolaus Kneidinger, MD","STUDY_CHAIR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":17,"email":43},"Grazyna Kwapiszewska-Marsh, PhD","CONTACT","004331638572918","grazyna.kwapiszewska-marsh@medunigraz.at",{"name":45,"role":41,"phone":46,"phoneExt":17,"email":47},"Johannes Lorenz Berg, PhD","004331638572917","johannes.berg@medunigraz.at",[49],{"facility":5,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Graz","Styria","8010","Austria","AT",{"type":57,"coordinates":58},"Point",[59,60],15.44197,47.06733,{"lat":60,"lon":59},[63],{"name":36,"role":41,"phone":64,"phoneExt":17,"email":65},"004331638513305","nikolaus.kneidinger@medunigraz.at",{"type":67,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[69],{"name":70,"class":6},"Medical University of Vienna","100631251",false,"NCT07498244","Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients","Inclusion criteria:\n\nPatients undergoing lung transplantation with COPD or PF, with or without associated PH and PAH.\n\n\\- Outpatient cohort with COPD or PF, with or without associated PH or PAH.\n\nExclusion criteria:\n\n* Presence of other lung diseases\n* Signs of infection, such as pneumonia, pulmonary tuberculosis, or pleural effusions.",true,"ALL","18 Years",{"count":80,"type":81},80,"ESTIMATED","OBSERVATIONAL","Chronic lung diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) can lead to pulmonary hypertension. This serious complication involves increased pressure in the lung vessels, which strains the heart and worsens outcomes. Since the early symptoms are unclear, diagnosis often occurs too late, underscoring the need for simple, noninvasive methods of early detection.\n\nA key driver of the disease is vascular remodeling, which involves the narrowing and stiffening of blood vessels. This process involves changes in the extracellular matrix, particularly in the understudied basement membrane. Our project examines how specific components, especially non-classical collagens, change during disease progression. As vessels remodel, detectable fragments enter the bloodstream, potentially creating a molecular fingerprint of the disease.\n\nBy analyzing lung tissue and blood samples, the investigators aim to identify non-invasive biomarkers for earlier diagnosis, better patient classification, and more personalized treatment.",[85],"Pulmonary Hypertension Due to Lung Diseases",[87],"Collagens","2026-03-30",{"date":90,"type":91},"2026-04-03","ACTUAL",{"date":93,"type":81},"2026-07-01",{"date":95,"type":81},"2030-06-30",{"name":5,"class":6},1]