[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100125189":3},{"organization":4,"outcomesModule":7,"designInfo":19,"detailedDescription":22,"studyPopulation":23,"armGroups":24,"interventions":35,"overallOfficials":56,"centralContacts":61,"locations":67,"responsibleParty":98,"collaborators":101,"id":105,"slug":11,"hasResults":106,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":11,"eligibilityCriteria":110,"healthyVolunteers":106,"sex":111,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":11,"studyType":117,"phases":11,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":90,"whyStopped":11,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},{"fullName":5,"class":6},"Vanderbilt-Ingram Cancer Center","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":11},[9],{"measure":10,"description":11,"timeFrame":12},"Protein and RNA expression fingerprints from collected samples",null,"after collection of designated samples",[14,17],{"measure":15,"description":11,"timeFrame":16},"Development of statistical and computational methods to model relationship of data and clinical outcomes","after laboratory gene analysis work is completed",{"measure":18,"description":11,"timeFrame":12},"Correlation of protein and RNA expression fingerprints with recurrence (local and\u002For distant) and survival",{"allocation":11,"interventionModel":11,"interventionModelDescription":11,"primaryPurpose":11,"observationalModel":20,"timePerspective":21,"maskingInfo":11},"COHORT","PROSPECTIVE","OBJECTIVES:\n\n* Develop statistical and computational methods for modeling the relationships between multiple variable protein and RNA expression data and clinical endpoints using both supervised and unsupervised classification and pattern recognition approaches.\n* Determine protein and RNA expression fingerprints on completely resected non-small cell lung cancer without prior chemotherapy.\n* Correlate protein and RNA expression fingerprints with T-stage and nodal involvement at the time of surgery, and collect outcome data to allow correlation with recurrence (local and\u002For distant) and survival.\n\nOUTLINE: This is a multicenter study.\n\nAny excess tissues removed from surgery and would otherwise be discarded (tissues not used for diagnosis and\u002For treatment decision making) are obtained for this study. Tissue are analyzed for molecular features that predict biologic behavior. Quantitation of RNA, gene expression profiles, and protein expression patterns are assessed by matrix-assisted laser desorption\u002Fionization time of flight mass spectroscopy and microarray analysis.\n\nMedical records are reviewed to obtain information about results of tests associated with cancer diagnosis. Further progress in cancer treatment and tumor behavior after surgery are followed via record review.","People who have clinical stage I and II non-small cell lung cancer",[25],{"label":26,"type":11,"description":27,"interventionNames":28},"Resectable non-small cell lung cancer","Patients with clinical stage I or II invasive lung cancer that can be completely removed by surgery and who have not undergone chemotherapy or radiotherapy before surgery",[29,30,31,32,33,34],"Genetic: gene expression analysis","Genetic: microarray analysis","Genetic: protein expression analysis","Other: biologic sample preservation procedure","Other: laboratory biomarker analysis","Other: matrix-assisted laser desorption\u002Fionization time of flight mass spectrometry",[36,41,44,47,50,53],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"GENETIC","gene expression analysis","Blood and lung tissue collection",[26],{"type":37,"name":42,"description":39,"armGroupLabels":43,"otherNames":11},"microarray analysis",[26],{"type":37,"name":45,"description":39,"armGroupLabels":46,"otherNames":11},"protein expression analysis",[26],{"type":6,"name":48,"description":39,"armGroupLabels":49,"otherNames":11},"biologic sample preservation procedure",[26],{"type":6,"name":51,"description":39,"armGroupLabels":52,"otherNames":11},"laboratory biomarker analysis",[26],{"type":6,"name":54,"description":39,"armGroupLabels":55,"otherNames":11},"matrix-assisted laser desorption\u002Fionization time of flight mass spectrometry",[26],[57],{"name":58,"affiliation":59,"role":60},"Eric Grogan, MD","Vanderbilt Medical Center","PRINCIPAL_INVESTIGATOR",[62],{"name":63,"role":64,"phone":65,"phoneExt":11,"email":66},"VICC Clinical Trials Information Program","CONTACT","800-811-8480","cip@vumc.org",[68,82,89],{"facility":69,"status":70,"city":71,"state":72,"zip":73,"country":74,"countryCode":75,"cosmosGeoPoint":76,"geoPoint":81,"contacts":11},"Dan Rudy Cancer Center at Saint Thomas Hospital","COMPLETED","Nashville","Tennessee","37205","United States","US",{"type":77,"coordinates":78},"Point",[79,80],-86.78444,36.16589,{"lat":80,"lon":79},{"facility":83,"status":84,"city":71,"state":72,"zip":85,"country":74,"countryCode":75,"cosmosGeoPoint":86,"geoPoint":88,"contacts":11},"Veterans Affairs Medical Center - Nashville","SUSPENDED","37212",{"type":77,"coordinates":87},[79,80],{"lat":80,"lon":79},{"facility":5,"status":90,"city":71,"state":72,"zip":91,"country":74,"countryCode":75,"cosmosGeoPoint":92,"geoPoint":94,"contacts":95},"RECRUITING","37232-6838",{"type":77,"coordinates":93},[79,80],{"lat":80,"lon":79},[96],{"name":97,"role":64,"phone":65,"phoneExt":11,"email":11},"Clinical Trials Office - Vanderbilt-Ingram Cancer Center",{"type":60,"investigatorFullName":99,"investigatorTitle":100,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Eric Grogan","Associate Professor of Thoracic Surgery",[102],{"name":103,"class":104},"National Cancer Institute (NCI)","NIH","100125189",false,"NCT00897117","Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer","Molecular Fingerprinting of Lung Cancer","Inclusion criteria\n\n* Diagnosis of non-small cell lung cancer\n\n  * Clinical stage I and II disease\n  * Resectable disease and complete surgical resection planned\n* Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network\n* Tumor specimen samples must be available at resection\n\nExclusion criteria\n\n* Chemotherapy before surgery\n* Radiotherapy before surgery","ALL","18 Years","120 Years",{"count":115,"type":116},4000,"ESTIMATED","OBSERVATIONAL","RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer.\n\nPURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.",[120],"Lung Cancer",[122,123],"stage I non-small cell lung cancer","stage II non-small cell lung cancer","2025-09-22",{"date":126,"type":127},"2025-09-26","ACTUAL",{"date":129,"type":11},"2001-05",{"date":131,"type":116},"2031-05-31",{"name":5,"class":6},3]