[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616174":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":26,"responsibleParty":40,"collaborators":26,"id":43,"slug":26,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":44,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":26,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":68,"whyStopped":26,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":26},{"fullName":5,"class":6},"Universitas Muhammadiyah Surakarta","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Combination of Snakehead Fish Powder + Bitter Melon Extract","EXPERIMENTAL","Participants in the experimental group will receive a combined herbal supplement containing Channa striata (snakehead fish) powder and Momordica charantia L. (bitter melon) extract.\n\nThe supplement is provided in capsule form containing 500 mg per day, administered for 4 weeks.",[13],"Dietary Supplement: Snakehead Fish Powder + Bitter Melon Extract",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Capsule","PLACEBO_COMPARATOR","Participants in the control group will receive placebo capsules identical in appearance, administered once daily for 4 weeks, with no active herbal ingredients",[19],"Other: Placebo Capsule",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Snakehead Fish Powder + Bitter Melon Extract","A 500 mg\u002Fday capsule containing a combination of:\n\n* Channa striata (snakehead fish) powder\n* Momordica charantia (bitter melon) ethanol extract Administered orally once daily for 4 weeks",[9],null,{"type":6,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Capsule identical in size, shape, and color to the intervention capsule, without active ingredients.\n\nAdministered orally once daily for 4 weeks.",[15],[31],{"name":32,"affiliation":5,"role":33},"FIK UMS","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":26,"email":39},"Fahrun Nur Rosyid, Doctoral degree","CONTACT","+62 8123183523","fnr100@ums.ac.id",{"type":33,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Fahrun Nur Rosyid","Head of Quality Assurance Group","100616174",false,"NCT07302178","Combined Bitter Melon Extract and Snakehead Fish Powder Supplementation for Glycemic Control in Type 2 Diabetes","Effect of Combined Bitter Melon (Momordica Charantia L.) Extract and Snakehead Fish (Channa Striata) Powder Supplementation on Glycemic Status in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Trial","BM-SF Glycemia","Inclusion Criteria:\n\n* Diagnosed with Type 2 Diabetes Mellitus (DMT2).\n* Fasting plasma glucose ≥ 126 mg\u002FdL and ≤ 200 mg\u002FdL or random blood glucose between 200-300 mg\u002FdL.\n* Age 20-65 years\n* Duration of diabetes 0-15 years.\n* Currently using one class of oral antidiabetic medication (biguanide: metformin).\n* Willing to participate and sign written informed consent.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding; or having impaired kidney or liver function (serum creatinine \\> 1.5 mg\u002FdL; SGOT\u002FSGPT \\> 2× upper limit).\n* Allergy to snakehead fish powder (Channa striata) or bitter melon extract (Momordica charantia).\n* Using antidiabetic medications other than metformin, or unable\u002Funwilling to comply with study procedures.","ALL","20 Years","65 Years",{"count":54,"type":55},80,"ESTIMATED","INTERVENTIONAL",[58],"NA","Type 2 diabetes mellitus (T2DM) remains a major global health problem due to its high prevalence, long-term complications, and substantial economic burden. Conventional antidiabetic therapies, including insulin and oral hypoglycemic agents, may cause significant side effects during long-term use and are contraindicated in certain clinical conditions. Therefore, safe and effective herbal-based alternatives are needed.\n\nPrevious preclinical and early clinical studies have shown that bitter melon (Momordica charantia L.) and snakehead fish (Channa striata) possess antidiabetic and anti-inflammatory properties, including improvement in glucose regulation, stimulation of insulin secretion, and regeneration of pancreatic cells. However, clinical evidence on their combined use remains limited.\n\nThis randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effect of daily supplementation with a combination of bitter melon extract and snakehead fish powder on glycemic status in adults with Type 2 diabetes mellitus. Ninety eligible participants will be randomly assigned to a treatment group receiving 500 mg\u002Fday of the herbal combination or a placebo for 4 weeks. Glycemic status will be assessed primarily through glycated albumin (GA) levels.\n\nThe findings of this study are expected to provide scientific evidence regarding the safety and efficacy of this herbal combination as a complementary antidiabetic therapy.",[61,62],"Type 2 Diabetes Mellitus (T2DM)","Hyperglycemia",[64,65,66,67],"Bitter melon extract","Momordica charantia","Channa striata","Glycemic status","NOT_YET_RECRUITING","2025-12-11",{"date":71,"type":72},"2025-12-24","ACTUAL",{"date":74,"type":55},"2026-01-01",{"date":76,"type":55},"2026-06-01",{"name":5,"class":6}]