[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560972":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":23,"responsibleParty":46,"collaborators":48,"id":51,"slug":7,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":7,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":7,"maxAge":7,"enrollmentInfo":58,"targetDuration":7,"studyType":61,"phases":7,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":26,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Michele Introna, M.d.","Fondazione IRCCS Istituto Neurologico C. Besta","PRINCIPAL_INVESTIGATOR",[14,19],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Michele Introna, M.D.","CONTACT","00390223942420","michele.introna@istituto-besta.it",{"name":20,"role":16,"phone":21,"phoneExt":7,"email":22},"Marco Gemma, M.D.","0039022394.2411","marco.gemma@istituto-besta.it",[24,36],{"facility":25,"status":26,"city":27,"state":28,"zip":29,"country":28,"cosmosGeoPoint":30,"geoPoint":35,"contacts":7},"Foundation IRCCS Carlo Besta Neurological Institute","RECRUITING","Milan","Italy","20133",{"type":31,"coordinates":32},"Point",[33,34],9.18951,45.46427,{"lat":34,"lon":33},{"facility":11,"status":26,"city":27,"state":37,"zip":29,"country":28,"cosmosGeoPoint":38,"geoPoint":42,"contacts":43},"Milano",{"type":31,"coordinates":39},[40,41],12.59836,42.78235,{"lat":41,"lon":40},[44],{"name":15,"role":16,"phone":45,"phoneExt":7,"email":18},"0223942420",{"type":47,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[49],{"name":50,"class":6},"University Medical Center Groningen","100560972",false,"NCT06584097","COMparative Performance of General Purpose Models","COMparative Performance of General Purpose Models for Propofol And REmifentanil in Neurosurgical Patients Admitted to the Intensive Care Unit","Inclusion Criteria:\n\n* Adult patients undergoing elective neurosurgical procedures with an expected sedation after surgery of \\> 12 hours • Requirement for an arterial line\n\nExclusion Criteria:\n\n* Pregnancy\n\n  * Known sensitivity or allergy to propofol or remifentanil\n  * Patient participating in research for which a period of exclusion is currently required by other study protocol, ethical committee or health authority.\n  * Age \\\u003C 18 years old\n  * Patients subjected to infusion of propofol and\u002For remifentanil not delivered through TCI pumps before the inclusion\n  * Patients exposed to other sedatives (benzodiazepines, volatile anesthetics, quetiapine) before the inclusion","ALL",{"count":59,"type":60},42,"ESTIMATED","OBSERVATIONAL","To compare the performance of the Eleveld models for propofol and remifentanil on neurosurgery patients admitted to intensive care with their intraoperative performance.",[64],"Neurosurgical Patients",[66,67,68,69],"Neuroanesthesia","total intravenous anesthesia","target controlled infusion","PKPD modelling","2026-02-10",{"date":72,"type":73},"2026-02-12","ACTUAL",{"date":75,"type":73},"2024-10-02",{"date":77,"type":60},"2026-12-31",{"name":5,"class":6},2]