Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

ConditionsPleural Effusion Heart Failure Malignant Neoplasm Fluid Overload Hypoalbuminemia Renal Failure Cirrhosis Infections

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorChinese University of Hong Kong

About this trial

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Eligibility criteria

Qualifiers

Patients hospitalized for heart failure and pleural effusion

Pleural tapping indicated for pleural fluid analysis.

Aged 18 years old or above

Disqualifiers

History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.

History of surgical decortication or pleurodesis in the ipsilateral pleural space.

Ipsilateral thoracic or cardiac surgery in the past 3 months.

Failure to obtain informed consent due to the patient's refusal or cognitive impairment.

Trial design

Treatments tested in this trial

Not listed

Trial groups

120 Participants

are grouped into 2 trial groups

Locations

Prince of Wales Hospital0000, Hong KongNew Territories, Hong Kong

Sponsors and collaborators

Chinese University of Hong Kong

Lead sponsor

Roche Diagnostics GmbH

Collaborator

Source ClinicalTrials.gov