[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500545":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":24,"responsibleParty":41,"collaborators":45,"id":49,"slug":10,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":10,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":10,"enrollmentInfo":57,"targetDuration":60,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":72,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Heart Failure-Associated Pleural Effusion",null,"Patients with pleural effusion with an underlying aetiology of heart failure",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Patients with pleural effusion due to exudative, or non-fluid overload causes",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Christopher Chan, MBChB","CONTACT","35053396","christopherchan@cuhk.edu.hk",{"name":22,"role":18,"phone":19,"phoneExt":10,"email":23},"Ken KP Chan, MBChB","chankapang@cuhk.edu.hk",[25],{"facility":26,"status":27,"city":28,"state":29,"zip":30,"country":28,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Prince of Wales Hospital","RECRUITING","Hong Kong","New Territories","0000",{"type":32,"coordinates":33},"Point",[34,35],114.17469,22.27832,{"lat":35,"lon":34},[38],{"name":17,"role":18,"phone":39,"phoneExt":40,"email":20},"85235052211","7607",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Christopher Chan","Honorary Clinical Tutor",[46],{"name":47,"class":48},"Roche Diagnostics GmbH","INDUSTRY","100500545",false,"NCT05797649","Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)","Comparing N-terminal-proB-type Natriuretic Peptide with Other Diagnostic Criteria in Discriminating Heart Failure-associated from Non-heart Failure-associated Pleural Effusions","Inclusion Criteria:\n\n* Patients hospitalized for heart failure and pleural effusion\n* Pleural tapping indicated for pleural fluid analysis.\n* Aged 18 years old or above\n\nExclusion Criteria:\n\n* History of intrapleural therapy (including talc and fibrinolytic) in the ipsilateral pleural space.\n* History of surgical decortication or pleurodesis in the ipsilateral pleural space.\n* Ipsilateral thoracic or cardiac surgery in the past 3 months.\n* Failure to obtain informed consent due to the patient's refusal or cognitive impairment.","ALL","18 Years",{"count":58,"type":59},120,"ESTIMATED","24 Months","OBSERVATIONAL","To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).",[64,65,66,67,68,69,70,71],"Pleural Effusion","Heart Failure","Malignant Neoplasm","Fluid Overload","Hypoalbuminemia","Renal Failure","Cirrhosis","Infections",[73,74,75,76,77,78,79,80],"pleural fluid","heart failure","malignancy","cancer","echocardiography","infection","tuberculosis","respiratory medicine","2024-11-11",{"date":83,"type":84},"2024-11-13","ACTUAL",{"date":86,"type":84},"2023-07-01",{"date":88,"type":59},"2025-11-30",{"name":5,"class":6},1]