Non-RCT clinical trial comparing 5-ALA photodynamic therapy and CO2 laser for persistent high-risk HPV-related low-grade cervical lesions.
Aged 18-65 years old with a history of sexual activity.
Subclinical infected individuals who have been confirmed as HR-HPV positive (if there is the same positive type in the typing test) for more than 1 year using HPV typing test, HPV E6/E7 mRNA test, HPV DNA test, and cervical triple step diagnostic procedure (cytology colposcopy histopathology).
Patients diagnosed with LSIL by pathological examination of cervical biopsy under colposcopy with an interval of more than 1 year.
No fundamental diseases of important organs.
HR-HPV persistent infection.
A total hysterectomy has been performed.
Concomitant endometrial cancer, ovarian cancer, and other reproductive tract tumors.
Complicated with abnormal heart, liver, and kidney functions, immune dysfunction, or immune system diseases such as systemic lupus erythematosus (SLE).
First Affiliated Hospital of Wenzhou Medical University
Lead sponsor