Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorUniversity Hospital, Lille
About this trial
The main objective of this study is the comparison of the profile of the pro-inflammatory cytokines at the patients suffering from an alcoholic hepatitis to that of two groups witnesses: patients suffering from an alcoholic cirrhosis and unhurt patients of chronic liver disease
Eligibility criteria
Qualifiers
group A: patients with acute alcoholic hepatitis
Active alcohol abuse defined by DSM IV and excessive alcohol consumption prior to admission (> 60 g per day for men and> 40 g per day for women)
Moderate elevation of transaminases (less than 500 U / L) with a typical ASAT / ALAT ratio of 2: 1
Bilirubin> 50 mg / l
Disqualifiers
Patients with hepatocellular carcinoma of progressive non-hepatic cancer
Presence of HBsAg
Presence of anti-HCV antibodies by positive PCR
Presence of antibodies to HIV 1 +2
Trial design
Treatments tested in this trial
- collection of liver biopsies collection of blood samples
Treatment groups
450 Participants
are divided into 3 treatment groupsLocations
1Hôpital Claude Huriez, CHRU Lille France
Sponsors and collaborators
University Hospital, Lille
Lead sponsor
Source ClinicalTrials.gov