[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537025":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":61,"collaborators":26,"id":64,"slug":26,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":26,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University Tunis El Manar","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IV-Lido","EXPERIMENTAL","Intravenous Lidocaine dose loading than continuous infusion",[13],"Drug: Lidocaine IV",{"label":15,"type":16,"description":17,"interventionNames":18},"IV-Keta","ACTIVE_COMPARATOR","Intravenous Ketamine dose loading than continuous infusion",[19],"Drug: Ketamine Injectable Solution",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Lidocaine IV","Intravenous Lidocaine Vs intravenous Ketamine in colorectal surgery for cancer",[9],null,{"type":22,"name":28,"description":24,"armGroupLabels":29,"otherNames":26},"Ketamine Injectable Solution",[15],[31],{"name":32,"affiliation":33,"role":34},"BEN ALI MECHAAL, Professor","university manar Tunis, Tunisia","PRINCIPAL_INVESTIGATOR",[36,41],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","72100533","00216","mechaal_benali@yahoo.fr",{"name":42,"role":37,"phone":43,"phoneExt":39,"email":44},"KTATA HIBA, Dr","72100500","Hibetallah.ktata@fmt.utm.tn",[46],{"facility":47,"status":48,"city":49,"state":26,"zip":50,"country":47,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Tunisia","RECRUITING","Nabeul","8000",{"type":52,"coordinates":53},"Point",[54,55],10.73763,36.45606,{"lat":55,"lon":54},[58],{"name":59,"role":37,"phone":60,"phoneExt":39,"email":40},"BEN ALI MECHAAL","53890987",{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"HibetAllah Ktata","Associate Professor","100537025",false,"NCT06272461","Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery","The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial","INCLUSION CRITERIA:\n\n* Patients aged 18 or older.\n* American society of anesthesiologists' (ASA) physical status of I-III.\n* Elective open colorectal surgery.\n\nNON INCLUSION CRITERIA:\n\n* Patients with contraindications to lidocaine or ketamine.\n* Corticosteroid therapy within the last 6 months.\n* History of immunosuppressive therapy.\n* History of surgery in the last 3 months.\n* Personal medical history of inflammatory bowel disease.\n* Personal medical history of cardiac arrythmias or conduction disorders.\n* Alcohol or drug abuse.\n* Chronic use of opioids or benzodiazepines.\n\nEXCLUSION CRITERIA:\n\n* Severe intraoperative complications.\n* Duration of surgery longer than 5 hours.","ALL","18 Years","90 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"NA","Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).\n\nFor the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.\n\nFor the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.\n\nPlasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.",[81,82],"Colorectal (Colon or Rectal) Cancer","Inflammation","2025-11-15",{"date":85,"type":86},"2025-11-18","ACTUAL",{"date":88,"type":86},"2023-10-01",{"date":90,"type":75},"2026-03-30",{"name":5,"class":6},1]