Health TrialsbyHealthPanel

Comparison of Rate of Complete Abortion Between Letrozole Plus Misoprostol vs Misoprostol Alone

ConditionMedical; Abortion, Fetus
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
AgeNot listed
SponsorQueen Savang Vadhana Memorial Hospital, Thailand

About this trial

Comparison of rate of complete abortion between Letrozole plus Misoprostol versus Misoprostol alone in first trimester pregnancy

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diafnoed Early pregnancy loss by TVS according to ACOG Practice bulletin 2018

GA <= 14 weeks

Os open <= 1 cm and no conceptus per os

Hematicrit >= 30

Disqualifiers

Allerguc to Letrozole or Misoprostol

Intrauterine contraceptive device use

Breast feeding

Diagnoed with ectopic pregnancy or undiagnoed adnexal mass

Trial design

Design model

Sequential

Treatments tested in this trial

  • Letrozole

    Drug

    In the experimental group, we give the Letrozole 10 mg PO daily on the 4th day before Misoprostol 800 mcg SL on the 4th day. In the control group, we give Misoprostol 800 mcg SL on the 4th day.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: Letrozole plus MisoprostolExperimental treatment 1 intervention
Group B: MisoprostolActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Rate of complete abortion

Rate of complete abortion

Time frame
up to 7 days

Secondary outcomes

1

Side effect between both group

Number of patients with side effects between both group

Time frame
up to 7 days
2

induced to abortion time between both group

induced to abortion time between both group

Time frame
up to 6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Queen Savang Vadhana Memorial Hospital, Thailand

Lead sponsor

Source ClinicalTrials.gov
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