[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626744":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":39,"responsibleParty":53,"collaborators":24,"id":57,"slug":24,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":24,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":24,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"State University of New York at Buffalo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Desinfection device","ACTIVE_COMPARATOR","Ultrasonic Activation: Piezoelectric ultrasonic unit (Dentsply International) with an Irrisafe tip (Satelec\u002FActeon).",[13],"Device: Desinfection device",{"label":15,"type":10,"description":16,"interventionNames":17},"Analytical microbiological method","qPCR assay: Quantifies total bacterial DNA using 16S rRNA gene amplification.",[18],"Device: Analytical microbiological methods",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Desinfection protocol with (LAI): Er,Cr:YSGG laser (2780 nm) delivered with a radial-firing tip.",[9],null,{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Analytical microbiological methods","Endocator: Measures ATP levels (Endoscore and RLU) to rapidly assess bacterial load in less than one minute.",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Stephen Lyon, DDS","CONTACT","(716) 829-6229","smlyon@buffalo.edu",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Thamyres Monteiro, MSc","(716) 829-6199","thamyres@buffalo.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":24},"Advance Education in Endodontics Program","RECRUITING","Buffalo","New York","14214","United States",{"type":48,"coordinates":49},"Point",[50,51],-78.87837,42.88645,{"lat":51,"lon":50},{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Stephen M. Lyon, D.D.S","Principal Investigator","100626744",false,"NCT07439614","Comparison of Root Canal Desinfection Protocols","Comparison of Different Root Canal Disinfection Protocols for Bacterial Reduction in Teeth With Apical Periodontitis Using Two Analytical Microbiological Methods: a Randomized Clinical Study","Inclusion Criteria:\n\n* Adult patients able to give informed consent and willing\u002Fable to comply with study procedures and follow-up.\n* Molar teeth indicated for endodontic treatment.\n* Teeth with intact pulp-chamber walls (no extensive coronal destruction).\n* Necrotic pulp confirmed by pulp testing.\n* Clinical and radiographic evidence of asymptomatic apical periodontitis.\n\nExclusion Criteria:\n\n* Immature teeth\n* Teeth with calcified or obliterated canals\n* Teeth with extensive coronal destruction\n* Teeth with previous endodontic treatment\n* Symptomatic apical periodontitis\n* Teeth with periodontal pockets greater than 4 mm\n* Patients who have received systemic antibiotics in the last 3 months\n* Patients with a history of diabetes or immune impairment\n* Pregnant patients",true,"ALL","18 Years","70 Years",{"count":68,"type":69},50,"ESTIMATED","INTERVENTIONAL",[72],"NA","Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis",[75],"Periapical Periodontitis","2026-06-18",{"date":78,"type":79},"2026-06-23","ACTUAL",{"date":81,"type":79},"2026-04-01",{"date":83,"type":69},"2027-06",{"name":5,"class":6},1]