[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593202":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":12,"centralContacts":24,"locations":12,"responsibleParty":30,"collaborators":12,"id":34,"slug":12,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":12,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":12,"studyType":47,"phases":48,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":57,"whyStopped":12,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":12},{"fullName":5,"class":6},"Mashhad University of Medical Sciences","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"natural cycle group","NO_INTERVENTION","A transvaginal ultrasound is performed on cycle day 2 or 3 to rule out ovarian cysts and confirm an endometrial thickness \\\u003C5 mm. If eligible, patients are monitored from day 8 onward. Ovulation is tracked by assessing dominant follicle growth (≥15 mm), LH surge (≥17 IU\u002FL), and serum progesterone (\\>1.5 ng\u002FmL). Once ovulation is confirmed and endometrial thickness reaches ≥7 mm, FET is scheduled for 6 days post-LH surge or 5 days post-follicle collapse. Serum progesterone is measured one day before transfer; if \\\u003C10 ng\u002FmL, 400 mg\u002Fday progesterone is administered",null,{"label":14,"type":15,"description":12,"interventionNames":16},"Hormone Replacement Therapy (HRT)","EXPERIMENTAL",[17],"Drug: hormone replacement therapy (HRT) group",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":12},"DRUG","hormone replacement therapy (HRT) group","Estradiol valerate is initiated at 4 mg\u002Fday on day 2 of the menstrual cycle and is adjusted to 8 mg\u002Fday based on endometrial thickness. Once the endometrial thickness reaches ≥8 mm, progesterone supplementation is started (400 mg vaginal suppositories twice daily and 50 mg intramuscular injections daily) for 5 days before blastocyst transfer.",[14],[25],{"name":26,"role":27,"phone":28,"phoneExt":12,"email":29},"Malihe Mahmoudinia, Prof","CONTACT","09153047813","mahmoudiniam@mums.ac.ir",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"SPONSOR_INVESTIGATOR","Malihe Mahmoudinia","Associate Professor of obstetrics & Gynecology, Fellowship of infertility, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","100593202",false,"NCT07003373","Comparison of Two Protocols in Frozen Embryo Transfer","Comparison of the Pregnancy Outcomes of Frozen Embryo Transfer in the Natural Cycle vs. Artificial Cycle","Inclusion Criteria:\n\nRegular menstrual cycles\n\nMaternal age between 18 and 42 years\n\nNormal intrauterine cavity confirmed by pretreatment ultrasound or hysteroscopy\n\nBody Mass Index (BMI) less than 30 kg\u002Fm²\n\nNo ovulation disorders\n\nExclusion Criteria:\n\nNo embryos available for transfer (no embryo thawing)\n\nWithdrawal of patient consent to continue treatment\n\nFailure of dominant follicle development (in natural cycle group)\n\nInadequate endometrial response for transfer\n\nNo endometriosis grade 3 or higher\n\nThe participant provided written informed consent",true,"FEMALE","18 Years","42 Years",{"count":45,"type":46},112,"ESTIMATED","INTERVENTIONAL",[49],"NA","This randomized clinical trial evaluates two different endometrial preparation protocols-hormone replacement therapy (HRT) and natural cycle-for frozen embryo transfer (FET) in infertile women undergoing assisted reproductive technology (ART). The goal is to compare implantation, clinical pregnancy, and ongoing pregnancy outcomes.",[52],"IVF Outcomes",[54,55,56],"Natural cycle","Artificial cycle","Frozen embryo transfer","NOT_YET_RECRUITING","2025-05-25",{"date":60,"type":61},"2025-06-04","ACTUAL",{"date":63,"type":46},"2025-07-05",{"date":65,"type":46},"2026-07-05",{"name":32,"class":6}]