[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100460660":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":80,"collaborators":83,"id":88,"slug":10,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":10,"studyType":102,"phases":10,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Turku","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"OA cases",null,"Fifty adult patients who have hip osteoarthritis.",[13],"Procedure: Total hip arthroplasty",{"label":15,"type":10,"description":16,"interventionNames":17},"RA cases","Forty adult patients who have rheumatoid arthritis in the hip joint.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Non-arthritic controls","Twenty adult patients who go through trauma-based emergency total hip arthroplasty and do not have arthritis.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"PROCEDURE","Total hip arthroplasty","Hip joint replacement surgery. Elective for RA and OA cases.",[19,9,15],[29],{"name":30,"affiliation":31,"role":32},"Lea Mikkola, PhD","Turku Bioscience, University of Turku","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+358404143300","limikk@utu.fi",[39,51,55,66],{"facility":40,"status":41,"city":42,"state":43,"zip":10,"country":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":10},"PET-centre, University of Turku","ACTIVE_NOT_RECRUITING","Turku","Southwest Finland","Finland",{"type":46,"coordinates":47},"Point",[48,49],22.26869,60.45148,{"lat":49,"lon":48},{"facility":31,"status":41,"city":42,"state":43,"zip":10,"country":44,"cosmosGeoPoint":52,"geoPoint":54,"contacts":10},{"type":46,"coordinates":53},[48,49],{"lat":49,"lon":48},{"facility":56,"status":57,"city":42,"state":43,"zip":10,"country":44,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Turku University Hospital","RECRUITING",{"type":46,"coordinates":59},[48,49],{"lat":49,"lon":48},[62,65],{"name":63,"role":35,"phone":10,"phoneExt":10,"email":64},"Pjotr Sarantsin, MD","Pjotr.Sarantsin@tyks.fi",{"name":63,"role":32,"phone":10,"phoneExt":10,"email":10},{"facility":67,"status":57,"city":68,"state":69,"zip":10,"country":44,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Helsinki University Hospital","Espoo","Uusimaa",{"type":46,"coordinates":71},[72,73],24.6522,60.2052,{"lat":73,"lon":72},[76,79],{"name":77,"role":35,"phone":10,"phoneExt":10,"email":78},"Anna Vasara, MD, PhD","anna.vasara@hus.fi",{"name":77,"role":32,"phone":10,"phoneExt":10,"email":10},{"type":32,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lea Mikkola","Principal Investigator",[84,86],{"name":56,"class":85},"OTHER_GOV",{"name":87,"class":6},"Hospital District of Helsinki and Uusimaa","100460660",false,"NCT05278520","Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","OASEQ","Inclusion Criteria for the main (OA) study:\n\nCases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\nControls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.\n\n\\----\n\nInclusion Criteria for the Rheumatoid sub-study:\n\nAdult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\n\\----\n\nExclusion Criteria:\n\n* The body mass index must be below 35\n* Age \\\u003C 18 or \\> 74\n* The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.\n\nFor the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.",true,"ALL","18 Years","74 Years",{"count":100,"type":101},110,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.",[105,106],"Osteoarthritis, Hip","Rheumatoid Arthritis",[108,109,110,111,112],"Single-cell RNA sequencing","Spatial transcriptomics","Osteoarthritis","Rheumatoid arthritis","Spatial proteomics","2025-08-18",{"date":115,"type":116},"2025-08-24","ACTUAL",{"date":118,"type":116},"2023-01-11",{"date":120,"type":101},"2028-12",{"name":5,"class":6},4]