[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524196":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":39,"locations":47,"responsibleParty":64,"collaborators":67,"id":70,"slug":25,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":71,"sex":77,"minAge":78,"maxAge":25,"enrollmentInfo":79,"targetDuration":25,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":50,"whyStopped":25,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Hospital Clinic of Barcelona","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Conduction system pacing","EXPERIMENTAL","Pacing the His-Purkinje system.\n\nCrossover to biventricular pacing allowed in case of failed conduction system pacing: failed His bundle pacing and failed Left bundle branch pacing (high thresholds (\\>3.5V \u002F 1ms); no left bundle branch pacing criteria; no left bundle branch correction).\n\nElectrocardiographic optimization allowed in order to obtain the narrowest QRS.",[13],"Procedure: Conduction system pacing",{"label":15,"type":16,"description":17,"interventionNames":18},"Biventricular pacing","ACTIVE_COMPARATOR","Pacing from the right ventricular and coronary sinus lead. Electrocardiographic optimization with fusion-optimized intervals (FOI).\n\nCrossover from biventricular pacing to conduction system pacing will be allowed in the following situations: coronary sinus cannot be cannulated; no lateral or posterolateral branches; or phrenic stimulation.",[19],"Procedure: Biventricular pacing",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Conduction system pacing implant as a Resynchronization therapy.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Biventricular pacing implant",[15],[30,34,36],{"name":31,"affiliation":32,"role":33},"José Mª Tolosana, MD, PhD","Hospital Clínic de Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":32,"role":33},"Margarida Pujol López, MD",{"name":37,"affiliation":32,"role":38},"Lluís Mont, MD, PhD","STUDY_CHAIR",[40,45],{"name":41,"role":42,"phone":43,"phoneExt":25,"email":44},"Jose Mª Tolosana, MD, PhD","CONTACT","93 2271778 (2094)","tolosana@clinic.cat",{"name":35,"role":42,"phone":43,"phoneExt":25,"email":46},"mapujol@clinic.cat",[48],{"facility":49,"status":50,"city":51,"state":25,"zip":25,"country":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Hospital Clínic de Barcelona","RECRUITING","Barcelona","Spain",{"type":54,"coordinates":55},"Point",[56,57],2.15899,41.38879,{"lat":57,"lon":56},[60,62],{"name":61,"role":42,"phone":25,"phoneExt":25,"email":44},"JM Tolosana, MD, PhD",{"name":63,"role":42,"phone":25,"phoneExt":25,"email":25},"M Pujol Lopez, MD",{"type":33,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Josep Lluis Mont Girbau","Head of Arrhythmia Research.",[68],{"name":69,"class":6},"Institut d'Investigacions Biomèdiques August Pi i Sunyer","100524196",false,"NCT06105580","Conduction System Pacing vs Biventricular Pacing in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant","Conduction System Pacing vs Biventricular Resynchronization Therapy in Systolic Dysfunction and Wide QRS: Mortality, Heart Failure Hospitalization or Cardiac Transplant","CONSYST-CRT II","Inclusion Criteria:\n\n* Patient must indicate acceptance to participate in the study by signing an informed consent document.\n* Patient must be ≥ 18 years of age.\n* Left bundle branch block, QRS ≥130 and LVEF \\\u003C=35%. No indication of stimulation for AV block.\n* Non-left bundle branch block, QRS ≥150 and LVEF \\\u003C=35%.\n* Resynchronization therapy indication for ventricular dysfunction (LVEF \\\u003C40%) and indication of cardiac pacing for AV block.\n* LVEF \\\u003C=35% in NYHA class III or IV, atrial fibrillation and intrinsic QRS \\>=130 ms, provided a strategy to ensure biventricular capture is in place.\n\nExclusion Criteria:\n\n* Myocardial infarction, unstable angina or cardiac revascularization during the previous 3 months.\n* Pregnancy.\n* Participating currently in a clinical investigation that includes an active treatment.","ALL","18 Years",{"count":80,"type":81},320,"ESTIMATED","INTERVENTIONAL",[84],"NA","Conduction system pacing vs biventricular resynchronization therapy in systolic dysfunction and wide QRS: mortality, heart failure hospitalization or cardiac transplant (CONSYST-CRT II trial).\n\nSuperiority trial that aims to study the composite endpoint consisting of all-cause mortality, cardiac transplant or heart failure hospitalization at 12-month follow-up.",[87,88],"Cardiac Resynchronization Therapy","Heart Failure",[90,91,92],"left bundle branch pacing","biventricular pacing","cardiac resynchronization therapy","2026-03-30",{"date":95,"type":96},"2026-04-03","ACTUAL",{"date":98,"type":96},"2023-11-27",{"date":100,"type":81},"2028-01",{"name":5,"class":6},1]