[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634338":3},{"organization":4,"outcomesModule":7,"designInfo":88,"detailedDescription":97,"studyPopulation":11,"armGroups":98,"interventions":109,"overallOfficials":11,"centralContacts":114,"locations":120,"responsibleParty":175,"collaborators":11,"id":179,"slug":11,"hasResults":180,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":180,"sex":186,"minAge":187,"maxAge":11,"enrollmentInfo":188,"targetDuration":11,"studyType":191,"phases":192,"briefSummary":194,"conditions":195,"keywords":197,"overallStatus":140,"whyStopped":11,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":213},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":78},[9],{"measure":10,"description":11,"timeFrame":12},"Area under a mean arterial pressure (MAP) of 65 mmHg (mmHg x min)",null,"First 15 minutes after starting induction of general anesthesia. The start of anesthetic induction is defined as the administration of propofol as hypnotic induction agent.",[14,16,18,20,22,24,26,28,30,32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64,66,68,70,72,74,76],{"measure":15,"description":11,"timeFrame":12},"Area under a MAP of 60 mmHg (mmHg x min)",{"measure":17,"description":11,"timeFrame":12},"Area under a MAP of 50 mmHg (mmHg x min)",{"measure":19,"description":11,"timeFrame":12},"Area under a MAP of 40 mmHg (mmHg x min)",{"measure":21,"description":11,"timeFrame":12},"Area above a MAP of 100 mmHg (mmHg x min)",{"measure":23,"description":11,"timeFrame":12},"Area above a MAP of 110 mmHg (mmHg x min)",{"measure":25,"description":11,"timeFrame":12},"Area above a MAP of 120 mmHg (mmHg x min)",{"measure":27,"description":11,"timeFrame":12},"Area above a MAP of 140 mmHg (mmHg x min)",{"measure":29,"description":11,"timeFrame":12},"Duration of a MAP \u003C65 mmHg (min)",{"measure":31,"description":11,"timeFrame":12},"Duration of a MAP \u003C60 mmHg (min)",{"measure":33,"description":11,"timeFrame":12},"Duration of a MAP \u003C50 mmHg (min)",{"measure":35,"description":11,"timeFrame":12},"Duration of a MAP \u003C40 mmHg (min)",{"measure":37,"description":11,"timeFrame":12},"Duration of a MAP >100 mmHg (min)",{"measure":39,"description":11,"timeFrame":12},"Duration of a MAP >110 mmHg (min)",{"measure":41,"description":11,"timeFrame":12},"Duration of a MAP >120 mmHg (min)",{"measure":43,"description":11,"timeFrame":12},"Duration of a MAP >140 mmHg (min)",{"measure":45,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement \u003C65 mmHg",{"measure":47,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement \u003C60 mmHg",{"measure":49,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement \u003C50 mmHg",{"measure":51,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement \u003C40 mmHg",{"measure":53,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement >100 mmHg",{"measure":55,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement >110 mmHg",{"measure":57,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement >120 mmHg",{"measure":59,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with any MAP measurement >140 mmHg",{"measure":61,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP \u003C65 mmHg",{"measure":63,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP \u003C60 mmHg",{"measure":65,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP \u003C50 mmHg",{"measure":67,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP \u003C40 mmHg",{"measure":69,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP >100 mmHg",{"measure":71,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP >110 mmHg",{"measure":73,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP >120 mmHg",{"measure":75,"description":11,"timeFrame":12},"Absolute (n) and relative (%) number of patients with at least one 1-minute episode of a MAP >140 mmHg",{"measure":77,"description":11,"timeFrame":12},"Cumulative dose of norepinephrine indexed to body weight (µg kg-1)",[79,82,84,86],{"measure":80,"description":11,"timeFrame":81},"Acute kidney injury","Within the first 3 postoperative days",{"measure":83,"description":11,"timeFrame":81},"Nonfatal cardiac arrest",{"measure":85,"description":11,"timeFrame":81},"Myocardial infarction",{"measure":87,"description":11,"timeFrame":81},"Death",{"allocation":89,"interventionModel":90,"interventionModelDescription":11,"primaryPurpose":91,"observationalModel":11,"timePerspective":11,"maskingInfo":92},"RANDOMIZED","PARALLEL","TREATMENT",{"masking":93,"maskingDescription":11,"whoMasked":94},"DOUBLE",[95,96],"PARTICIPANT","OUTCOMES_ASSESSOR","Hypotension after induction of general anesthesia, referred to as postinduction hypotension, is common in patients having non-cardiac surgery and is associated with acute kidney injury. Risk factors for postinduction hypotension include older age, higher American Society of Anesthesiologists physical status, chronic arterial hypertension - and higher doses of vasodilating anesthetic drugs. It is reasonable to assume that careful anesthetic management can help maintain blood pressure stability and limit postinduction hypotension. Consistent with this assumption, continuous blood pressure monitoring with an arterial catheter during induction of general anesthesia helps clinicians reduce postinduction hypotension - and is thus recommended in non-cardiac surgery patients at risk for hypotension-related complications.\n\nBesides continuous monitoring, anesthesiologists routinely give vasopressors - such as norepinephrine - to maintain blood pressure. Norepinephrine is a fast acting vasopressor with a short half-life and is usually given as repeated manual boluses during induction of general anesthesia. Given as a bolus, it effectively and rapidly increases blood pressure. However, boluses need to be frequently repeated and well-timed to ensure blood pressure stability.\n\nIn a single-center randomized trial, we demonstrated that continuous - compared to bolus - administration of norepinephrine during induction of general anesthesia helps maintain blood pressure stability in high-risk non cardiac surgery patients. We now aim to test the hypothesis that continuous - compared to bolus - administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients who have continuous blood pressure monitoring with an arterial catheter.",[99,105],{"label":100,"type":101,"description":102,"interventionNames":103},"Continuous Norepinephrine Administration","EXPERIMENTAL","In patients assigned to continuous norepinephrine administration, norepinephrine will be administered continuously via a syringe infusion pump.",[104],"Procedure: Continuous Norepinephrine Administration",{"label":106,"type":107,"description":108,"interventionNames":11},"Bolus Norepinephrine Administration","NO_INTERVENTION","In patients assigned to manual bolus norepinephrine administration, norepinephrine will be given manually in bolus doses.",[110],{"type":111,"name":100,"description":112,"armGroupLabels":113,"otherNames":11},"PROCEDURE","In patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.",[100],[115],{"name":116,"role":117,"phone":118,"phoneExt":11,"email":119},"Kristen K Thomsen, MD","CONTACT","+4940741070215","kr.thomsen@uke.de",[121,138,152,162],{"facility":122,"status":123,"city":124,"state":11,"zip":11,"country":125,"countryCode":126,"cosmosGeoPoint":127,"geoPoint":132,"contacts":133},"Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin","NOT_YET_RECRUITING","Berlin","Germany","DE",{"type":128,"coordinates":129},"Point",[130,131],13.41053,52.52437,{"lat":131,"lon":130},[134],{"name":135,"role":117,"phone":136,"phoneExt":11,"email":137},"Sascha Treskatsch, MD","+49 30 450 551 522","sascha.treskatsch@charite.de",{"facility":139,"status":140,"city":141,"state":11,"zip":11,"country":125,"countryCode":126,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf","RECRUITING","Düsseldorf",{"type":128,"coordinates":143},[144,145],6.77927,51.22319,{"lat":145,"lon":144},[148],{"name":149,"role":117,"phone":150,"phoneExt":11,"email":151},"Sebastian Roth, MD","+49 211 81 16253","Sebastian.Roth@med.uni-duesseldorf.de",{"facility":153,"status":140,"city":154,"state":11,"zip":11,"country":125,"countryCode":126,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf","Hamburg",{"type":128,"coordinates":156},[157,158],9.99302,53.55073,{"lat":158,"lon":157},[161],{"name":116,"role":117,"phone":118,"phoneExt":11,"email":119},{"facility":163,"status":140,"city":164,"state":11,"zip":11,"country":125,"countryCode":126,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Department of Anaesthesiology, University Hospital LMU Munich","München",{"type":128,"coordinates":166},[167,168],13.31243,51.60698,{"lat":168,"lon":167},[171],{"name":172,"role":117,"phone":173,"phoneExt":11,"email":174},"Agnes Meidert, MD","+49 89 440081065","Agnes.meidert@med.uni-muenchen.de",{"type":176,"investigatorFullName":177,"investigatorTitle":178,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Kristen Thomsen","Principal Investigator","100634338",false,"NCT07538388","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension","Continuous Versus Bolus Norepinephrine Administration to Treat Postinduction Hypotension in High-Risk Non-Cardiac Surgery Patients - The Multicenter INDUCT Trial (INDUCT-Multi)","INDUCT-Multi","Inclusion Criteria:\n\nWe will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:\n\n* Age ≥65 years\n* ASA physical status III or IV\n* Chronic arterial hypertension\n* Diabetes mellitus requiring medication\n* Intra-abdominal surgery\n* Preoperative renal insufficiency (serum creatinine ≥1.2 mg\u002FdL)\n\nExclusion Criteria:\n\n* Pregnancy\n* Cardiac arrhythmia\n* History of intracranial hemorrhage or intracranial aneurysm\n* Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)\n* Patients who are unable to understand, read, and provide informed consent in German","ALL","45 Years",{"count":189,"type":190},446,"ESTIMATED","INTERVENTIONAL",[193],"NA","INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.",[196],"Postinduction Hypotension",[198,199,200,201,202,203],"postinduction hypotension","non-cardiac surgery","norepinephrine","bolus","hypotension","continuous","2026-06-24",{"date":206,"type":207},"2026-06-29","ACTUAL",{"date":209,"type":207},"2026-05-07",{"date":211,"type":190},"2026-12",{"name":5,"class":6},4]