[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100458941":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":57,"collaborators":25,"id":60,"slug":25,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":25,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":25,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"CVS subjects","EXPERIMENTAL","Subjects diagnosed with Cyclic Vomiting Syndrome (CVS)",[13,14],"Other: TMS Paired-Pulse assessment of cortical excitability","Other: Autonomic activity",{"label":16,"type":17,"description":18,"interventionNames":19},"healthy, non-CVS subjects","ACTIVE_COMPARATOR","Subjects not diagnosed with CVS",[13,14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"TMS Paired-Pulse assessment of cortical excitability","Using the paired-pulse TMS paradigm, intracortical inhibition and facilitation of cortical circuitry will be assessed by stimulating the motor cortex and using the electromyographic (EMG) response of a target muscle as readout. In such studies, a conditioning stimulus modulates the amplitude of the motor-evoked potential (MEP) produced by the test stimulus. Depending on the inter-stimulus interval, effects can be attributed to different aspects of cortical processing. Brief intervals (1-5 ms) will be used to assess short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF), intermediate intervals (7-20 ms) to assess intracortical facilitation (ICF) and long intervals (50-200 ms) to assess long-interval intracortical inhibition (LICI).",[9,16],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Autonomic activity","Autonomic function will be determined using continuously recorded EKG and used as covariates to investigate any systematic impact on cortical excitability measures collected with the paired-pulse protocols.",[9,16],[31],{"name":32,"affiliation":5,"role":33},"David J Levinthal, MD PhD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Paul HM Kullmann, PhD","CONTACT","412-647-1533","phmk@pitt.edu",{"name":32,"role":37,"phone":41,"phoneExt":25,"email":42},"412-303-0525","levinthald@upmc.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":25},"University of Pittsburgh Medical Center","RECRUITING","Pittsburgh","Pennsylvania","15232","United States",{"type":52,"coordinates":53},"Point",[54,55],-79.99589,40.44062,{"lat":55,"lon":54},{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"David Levinthal","Assistant Professor","100458941",false,"NCT05256160","Cortical Excitability in Cyclic Vomiting Syndrome","Inclusion Criteria:\n\n* diagnosis of CVS\n\nExclusion Criteria:\n\n* history of CVS (for healthy control population only)\n* psychosis or altered cognitive status\n* history of head injury, metal in the skull, stroke, or a history of seizures or a history of syncope (fainting or passing out)\n* implantable devices, such as a pacemaker or nerve stimulator\n* current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust\u002FPCP, cocaine, or 3 or more alcoholic drinks per day\n* pregnancy",true,"ALL","18 Years","60 Years",{"count":70,"type":71},110,"ESTIMATED","INTERVENTIONAL",[74],"NA","This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).",[77],"Cyclic Vomiting Syndrome","2025-08-21",{"date":80,"type":81},"2025-08-24","ACTUAL",{"date":83,"type":81},"2022-05-16",{"date":85,"type":71},"2027-06",{"name":5,"class":6},1]