[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644427":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":10,"locations":20,"responsibleParty":32,"collaborators":34,"id":41,"slug":10,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":10,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":10,"studyType":52,"phases":10,"briefSummary":53,"conditions":54,"keywords":10,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"The First Affiliated Hospital of Soochow University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cousin haplo-HSCT",null,"Patients who underwent haploidentical hematopoietic stem cell transplantation with cousin donors. Grouping was based on donor age recorded in retrospective clinical data.",{"label":13,"type":10,"description":14,"interventionNames":10},"Sibling haplo-HSCT","Patients who underwent haploidentical hematopoietic stem cell transplantation with sibling donors. Grouping was based on donor age recorded in retrospective clinical data.",[16],{"name":17,"affiliation":18,"role":19},"Yang Xu","The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China","PRINCIPAL_INVESTIGATOR",[21],{"facility":5,"status":10,"city":22,"state":23,"zip":24,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":10},"Suzhou","Jiangsu","215000","China",{"type":27,"coordinates":28},"Point",[29,30],120.59538,31.30408,{"lat":30,"lon":29},{"type":33,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[35,37,39],{"name":36,"class":6},"Ruijin Hospital",{"name":38,"class":6},"Nanfang Hospital, Southern Medical University",{"name":40,"class":6},"Zhejiang University","100644427",false,"NCT07662382","Cousin vs. Sibling Donors in Haplo-HSCT","Comparison of Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation From Cousin Donors Versus Sibling Donors in Patients With Hematological Malignancies: A Target Trial Emulation Study","Inclusion Criteria:\n\n* Adult patients diagnosed with hematological malignancies, including acute leukemia (AL), chronic myeloid leukemia (CML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and non-Hodgkin lymphoma (NHL)\n* Receipt of first haploidentical hematopoietic stem cell transplantation between 2017 and 2024\n* Documented exact date of transplantation available in medical charts\n* Verifiable donor kinship classified as either cousin or sibiling\n* Complete longitudinal follow-up data accessible for outcome assessment\n\nExclusion Criteria:\n\n* Prior receipt of any form of hematopoietic stem cell transplantation\n* An age difference of more than 18 years between the donor and recipient\n* Failure of successful infusion of donor-derived hematopoietic stem cells following conditioning regimen","ALL","18 Years",{"count":50,"type":51},1000,"ESTIMATED","OBSERVATIONAL","This observational study aims to emulate a hypothetical pragmatic, multicenter, non-blinded clinical trial enrolling adult patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with grafts derived from either cousin or sibiling donors.\n\nThe main research question is whether cousin donor-derived haplo-HSCT is associated with inferior clinical outcomes relative to sibling donor-derived haplo-HSCT.\n\nStudy participants consist of adult patients diagnosed with hematological malignancies who underwent cousin or sibiling haplo-HSCT between 2017 and 2024, and all eligible recipients will receive regular follow-up assessments.",[55,56,57],"Hematopoietic Malignancies","Haploidentical Hematopoietic Stem Cell Transplantation","Donor","NOT_YET_RECRUITING","2026-06-16",{"date":61,"type":62},"2026-06-23","ACTUAL",{"date":64,"type":51},"2026-08-01",{"date":66,"type":51},"2027-10-31",{"name":5,"class":6},1]