[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100526800":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":27,"centralContacts":32,"locations":42,"responsibleParty":116,"collaborators":11,"id":118,"slug":11,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":11,"eligibilityCriteria":123,"healthyVolunteers":119,"sex":124,"minAge":125,"maxAge":11,"enrollmentInfo":126,"targetDuration":11,"studyType":129,"phases":130,"briefSummary":132,"conditions":133,"keywords":11,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":145},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cryotherapy","EXPERIMENTAL",null,[13],"Behavioral: Cryotherapy",{"label":15,"type":10,"description":11,"interventionNames":16},"Compression with Cryotherapy",[13,17],"Behavioral: Compression",[19,23],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":11},"BEHAVIORAL","Participants will receive cryotherapy on both hands and feet",[15,9],{"type":20,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Compression","Participants will receive compression on both hands and feet",[15],[28],{"name":29,"affiliation":30,"role":31},"Laura Havrilesky","DUHS","PRINCIPAL_INVESTIGATOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":11,"email":37},"Amelia Scott","CONTACT","919-613-4584","amelia.lorenzo@duke.edu",{"name":39,"role":35,"phone":40,"phoneExt":11,"email":41},"Mary K Anastasio","225-603-7972","mm765@duke.edu",[43,63,80,96],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Hartford Healthcare Cancer Institute","NOT_YET_RECRUITING","Hartford","Connecticut","06106","United States",{"type":51,"coordinates":52},"Point",[53,54],-72.68509,41.76371,{"lat":54,"lon":53},[57,61],{"name":58,"role":35,"phone":59,"phoneExt":11,"email":60},"Corey Glider","860-972-5019","Corey.Glider@hhchealth.org",{"name":62,"role":31,"phone":11,"phoneExt":11,"email":11},"Amy Brown, MD",{"facility":64,"status":65,"city":66,"state":47,"zip":67,"country":49,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Middlesex Health Cancer Center - Middletown","RECRUITING","Middletown","06457",{"type":51,"coordinates":69},[70,71],-72.65065,41.56232,{"lat":71,"lon":70},[74,78],{"name":75,"role":35,"phone":76,"phoneExt":11,"email":77},"Loriann MacLean, MSN","860-358-2015","loriann.maclean@midhosp.org",{"name":79,"role":31,"phone":11,"phoneExt":11,"email":11},"Karthikeyan Kandevelou, MD",{"facility":81,"status":65,"city":82,"state":83,"zip":84,"country":49,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Duke University Medical Center","Durham","North Carolina","27710",{"type":51,"coordinates":86},[87,88],-78.89862,35.99403,{"lat":88,"lon":87},[91,95],{"name":92,"role":35,"phone":93,"phoneExt":11,"email":94},"Laura Havrilesky, MD","919-684-0126","laura.havrilesky@duke.edu",{"name":92,"role":31,"phone":11,"phoneExt":11,"email":11},{"facility":97,"status":65,"city":98,"state":99,"zip":100,"country":49,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Carilion Clinic","Roanoke","Virginia","24016",{"type":51,"coordinates":102},[103,104],-79.94143,37.27097,{"lat":104,"lon":103},[107,111,115],{"name":108,"role":35,"phone":109,"phoneExt":11,"email":110},"Danielle Mitchell","540-521-1355","dmmitchell@carilionclinic.org",{"name":112,"role":35,"phone":113,"phoneExt":11,"email":114},"Erin Saks, MD","(540) 581-0160","ejsaks@carilionclinic.org",{"name":112,"role":31,"phone":11,"phoneExt":11,"email":11},{"type":117,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100526800",false,"NCT06139458","Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer - COHORT 2","Use of Cryocompression to Reduce Chemotherapy-induced Peripheral Neuropathy in Gynecologic Cancer: a Randomized Controlled Trial - COHORT 2","Inclusion Criteria:\n\n* Gynecologic cancer diagnosis (ovarian, cervical, endometrial cancer; adenocarcinomas of likely primary gynecologic origin based on cytology or FNA in conjunction with radiologic impression will be eligible)\n* Plan to receive at least 6 cycles of paclitaxel administered every 3 weeks at the Duke Cancer Center or Macon Pond or at the Carilion Clinic in Roanoke, VA. Patients receiving neoadjuvant chemotherapy with a plan for interval debulking will be eligible.\n* ECOG (Eastern Cooperative Oncology Group) performance status of 0-1\n\nExclusion Criteria:\n\n* Treated with prior neurotoxic chemotherapeutic agents\n* Baseline diagnosis of peripheral neuropathy such as diabetic neuropathy, or conditions including but not limited to fibromyalgia, cryoglobulinemia and Raynaud's disease.","FEMALE","18 Years",{"count":127,"type":128},190,"ESTIMATED","INTERVENTIONAL",[131],"NA","The investigators aim to determine the effect of cryotherapy wraps plus compression therapy (henceforth referred to as cryocompression) versus cryotherapy wraps alone on the incidence and degree of chemotherapy-induced peripheral neuropathy in patients with gynecologic cancer using a noninferiority design. The investigators also aim to determine the effect of cryocompression versus cryotherapy on patient tolerability and patient and staff satisfaction.",[134,135],"Gynecologic Cancer","Chemotherapy-induced Peripheral Neuropathy","2026-06-01",{"date":138,"type":139},"2026-06-02","ACTUAL",{"date":141,"type":139},"2024-01-18",{"date":143,"type":128},"2027-05-31",{"name":5,"class":6},4]