[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100452958":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":18,"responsibleParty":35,"collaborators":38,"id":41,"slug":7,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":7,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":7,"maxAge":7,"enrollmentInfo":48,"targetDuration":51,"studyType":52,"phases":7,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Thomayer University Hospital","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Jan MD Chlumsky, PhD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Katerina Kusalova, Ing","CONTACT","+420723949465","kusalova@biostatistika.cz",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Thomayer university hospital","RECRUITING","Prague","Czech Republic","14059","Czechia",{"type":27,"coordinates":28},"Point",[29,30],14.42076,50.08804,{"lat":30,"lon":29},[33],{"name":34,"role":11,"phone":7,"phoneExt":7,"email":7},"Jan Chlumsky, MD",{"type":11,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Jan Chlumsky, M.D.","Principal Investigator",[39],{"name":40,"class":6},"Masaryk University","100452958",false,"NCT05178277","Czech AATD Registry","Czech Alpha-1 Antitrypsin Deficiency Registry, the National Observational Study.","Inclusion Criteria:\n\n* Patients with alpha-1-antitrypsin deficiency\n\nExclusion Criteria:\n\n* Patient disagreement with inclusion in the study","ALL",{"count":49,"type":50},300,"ESTIMATED","20 Years","OBSERVATIONAL","Alpha-1-antitrypsin deficiency is the most common congenital disease of the respiratory system, leading to early pulmonary emphysema or bronchiectasis. Pulmonary involvement significantly accelerates active cigarette smoking. Patients with alpha-1-antitrypsin deficiency may also have liver cirrhosis, vasculitis, skin or intestinal disorders.\n\nThe AATD Registry is a non-interventional multicenter retrospective prospective longitudinal follow-up of patients with alpha-1-antitrypsin deficiency.\n\nThe aim of the AATD National Registry is to collect and analyze clinical data in patients with alpha-1 antitrypsin deficiency.",[55],"Alpha-1-antitrypsin Deficiency",[57,58,59],"Alpha-1-antitrypsin deficiency","AATD","national registry","2021-12-16",{"date":62,"type":63},"2022-01-05","ACTUAL",{"date":65,"type":63},"2018-01-01",{"date":67,"type":50},"2035-12-31",{"name":5,"class":6},1]