[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598559":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":30,"locations":40,"responsibleParty":178,"collaborators":29,"id":181,"slug":29,"hasResults":182,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":29,"eligibilityCriteria":186,"healthyVolunteers":182,"sex":187,"minAge":188,"maxAge":189,"enrollmentInfo":190,"targetDuration":29,"studyType":193,"phases":194,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":43,"whyStopped":29,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":212},{"fullName":5,"class":6},"Beijing Tiantan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DC-LVA treatment plus usual care","EXPERIMENTAL","The intervention requires to perform bilateral deep cervical lymphatic venous anastomosis (DC-LVA). The usual care includes patients who were not using or were currently using medications for improving cognitive function.",[13],"Procedure: DC-LVA treatment plus usual care",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual care","ACTIVE_COMPARATOR","The usual care group includes patients who were not using or were currently using medications for improving cognitive function.",[19],"Other: Usual care",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Through cervical incision, the deep cervical lymphatic tissue is anatomically dissected and anastomosed with the venous system of the neck. Under indocyanine green (ICG) navigation, the flow of lymphatic fluid into the vein could be observed via ICG tracing fluorescence after surgery.",[9],[26],"LVA",{"type":6,"name":15,"description":17,"armGroupLabels":28,"otherNames":29},[15],null,[31,36],{"name":32,"role":33,"phone":34,"phoneExt":29,"email":35},"Yuesong Pan","CONTACT","0086-010-59975807","yuesongpan@aliyun.com",{"name":37,"role":33,"phone":38,"phoneExt":29,"email":39},"Yilong Wang","0086-010-67092222","yilong528@aliyun.com",[41,58,72,87,98,108,120,142,159],{"facility":42,"status":43,"city":44,"state":45,"zip":29,"country":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Dongguan Chashan Hospital","RECRUITING","Dongguan","Guangdong","China",{"type":48,"coordinates":49},"Point",[50,51],113.74866,23.01797,{"lat":51,"lon":50},[54],{"name":55,"role":33,"phone":56,"phoneExt":29,"email":57},"Haiwen Wang","0086-13609048317","shizetianv@163.com",{"facility":59,"status":43,"city":45,"state":60,"zip":61,"country":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Guangdong Second People's Hospital","Guangzhou","510000",{"type":48,"coordinates":63},[64,65],129.33635,42.76832,{"lat":65,"lon":64},[68],{"name":69,"role":33,"phone":70,"phoneExt":29,"email":71},"Ping Luan","13612992682","luanping@szu.edu.cn",{"facility":73,"status":43,"city":74,"state":75,"zip":76,"country":46,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Zhengzhou Central Hospital","Zhengzhou","Henan","450000",{"type":48,"coordinates":78},[79,80],113.64861,34.75778,{"lat":80,"lon":79},[83],{"name":84,"role":33,"phone":85,"phoneExt":29,"email":86},"Xiwen Ma","0086-13623805170","zmydocument@163.com",{"facility":88,"status":89,"city":90,"state":91,"zip":92,"country":46,"cosmosGeoPoint":93,"geoPoint":97,"contacts":29},"First Affiliated Hospital of Shandong First Medical University","ACTIVE_NOT_RECRUITING","Jinan","Shandong","250000",{"type":48,"coordinates":94},[95,96],116.99722,36.66833,{"lat":96,"lon":95},{"facility":99,"status":43,"city":90,"state":91,"zip":92,"country":46,"cosmosGeoPoint":100,"geoPoint":102,"contacts":103},"Shandong Provincial Public Health Clinical Center",{"type":48,"coordinates":101},[95,96],{"lat":96,"lon":95},[104],{"name":105,"role":33,"phone":106,"phoneExt":29,"email":107},"Qinghua Zhang","0086-15168863112","zhang.qinghua@outlook.com",{"facility":109,"status":43,"city":90,"state":91,"zip":92,"country":46,"cosmosGeoPoint":110,"geoPoint":112,"contacts":113},"Shandong Provincial Third Hospital",{"type":48,"coordinates":111},[95,96],{"lat":96,"lon":95},[114,118],{"name":115,"role":33,"phone":116,"phoneExt":29,"email":117},"Tingzhong Wang","0086-18900912311","wangtingzhong@126.com",{"name":115,"role":119,"phone":29,"phoneExt":29,"email":29},"PRINCIPAL_INVESTIGATOR",{"facility":121,"status":43,"city":122,"state":91,"zip":123,"country":46,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Jining First People's Hospital","Jining","272000",{"type":48,"coordinates":125},[126,127],116.58139,35.405,{"lat":127,"lon":126},[130,134,135,138,140],{"name":131,"role":33,"phone":132,"phoneExt":29,"email":133},"Lei Feng","0086-13181326326","flneuro@163.com",{"name":131,"role":119,"phone":29,"phoneExt":29,"email":29},{"name":136,"role":137,"phone":29,"phoneExt":29,"email":29},"Gaoyang Fan","SUB_INVESTIGATOR",{"name":139,"role":137,"phone":29,"phoneExt":29,"email":29},"Zhongrui Yan",{"name":141,"role":137,"phone":29,"phoneExt":29,"email":29},"Peng Wang",{"facility":143,"status":43,"city":144,"state":145,"zip":146,"country":46,"cosmosGeoPoint":147,"geoPoint":151,"contacts":152},"The First Affiliated Hospital of Ningbo University","Ningbo","Zhejiang","315000",{"type":48,"coordinates":148},[149,150],121.54945,29.87819,{"lat":150,"lon":149},[153,157],{"name":154,"role":33,"phone":155,"phoneExt":29,"email":156},"Xiang Gao","0086-18888611859","yehand120@163.com",{"name":158,"role":33,"phone":29,"phoneExt":29,"email":29},"Zhaohui Ye",{"facility":160,"status":43,"city":161,"state":29,"zip":162,"country":46,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"Beijing Tiantan Hopital, Capital Medical University","Beijing","100070",{"type":48,"coordinates":164},[165,166],116.39723,39.9075,{"lat":166,"lon":165},[169,173,175,177],{"name":170,"role":33,"phone":171,"phoneExt":29,"email":172},"Yijia Guo, phD","0086-010-59975029","guoyijia_cmu@163.com",{"name":174,"role":33,"phone":171,"phoneExt":29,"email":35},"Yuesong Pan, phD",{"name":176,"role":119,"phone":29,"phoneExt":29,"email":29},"Yilong Wang, PhD",{"name":174,"role":137,"phone":29,"phoneExt":29,"email":29},{"type":119,"investigatorFullName":179,"investigatorTitle":180,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"yilong Wang","Professor","100598559",false,"NCT07073066","Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease (CLEAN-AD)","Deep Cervical Lymphatic Venous Anastomosis in the Treatment of Alzheimer's Disease: A Multicenter, Prospective, Open-label, Blinded-Endpoint, Randomized Controlled Trial (CLEAN-AD)","Inclusion Criteria:\n\n1. Age 50-80 years, male or female.\n2. Diagnosed with AD according to NIA-AA criteria.\n3. Moderate-to-severe AD dementia, defined as Clinical Dementia Rating Scale Global Score (CDR-GS) ≥1.\n4. Mini-Mental State Examination (MMSE) score 10-20.\n5. The course of AD more than 6 months.\n6. If receiving an approved AD treatment, must be on a stable drug dose for at least 3 months prior to Baseline. AD Treatment-naïve subjects can be entered into the study.\n7. Have an identified caregiver (defined as a person able to support the subject for the duration of the study and who spends at least 8 hours per week with the subject). The caregiver must accompany with the participant at all study follow-up visits.\n8. Signed informed consent (from the participant or their relative, and the caregiver).\n\nExclusion Criteria:\n\n1. Any neurological condition other than AD that may affect cognitive function, including stroke, Parkinson's disease, epilepsy, intracranial tumors or space-occupying lesions, traumatic brain injury, intracranial infections, metabolic encephalopathy, etc.\n2. Other causes of dementia, including vascular dementia, hereditary cerebral small vessel disease, vitamin deficiency, or any other etiology leading to dementia.\n3. Previous evidence of severe stenosis (≥70%) in the middle cerebral artery and\u002For internal carotid artery.\n4. Presence of primary psychiatric disorders (such as schizophrenia, schizoaffective disorder, major depressive disorder, or bipolar disorder) rather than psychiatric symptoms caused by AD.\n5. Severe neurological deficits in limb movement, language, vision, hearing, or consciousness, or any condition that the investigator determines may prevent the completion of cognitive function assessments.\n6. History of drug or alcohol abuse or dependence.\n7. History of malignant tumors or prior radiotherapy or surgery involving the head and neck.\n8. Major surgical procedures or severe head or body trauma within the past 30 days.\n9. Presence of other life-threatening conditions with an expected survival time of less than 2 years.\n10. Contraindications to head MRI (including cardiac pacemakers\u002Fdefibrillators, ferromagnetic metal implants, etc.).\n11. Severe diseases or functional impairment of the heart, lungs, liver, kidneys, or other solid organs, making the patient unable to tolerate anesthesia or DC-LVA.\n12. Severe bleeding tendency (including but not limited to): platelet count \\\u003C100×10⁹\u002FL; heparin therapy within the last 48 hours with APTT ≥35 seconds; ongoing warfarin use with INR \\>1.7.\n13. Requirement for long-term use of antithrombotic medications, with inability to discontinue them before surgery or potential risks associated with discontinuation.\n14. Uncontrolled persistent hypertension (systolic blood pressure \\>160 mmHg or diastolic blood pressure \\>95 mmHg).\n15. Co-infection with HIV or Treponema pallidum, or any uncontrolled infectious disease.\n16. Use of other investigational drugs or devices within 30 days prior to obtaining informed consent, or current participation in other interventional clinical studies.\n17. Pregnancy, lactation, potential for pregnancy, or plans for pregnancy during the study period.\n18. Immediate family members of the investigator (spouse, parents, children, or siblings), staff of the research institution or third-party organizations, or any other individuals with potential conflicts of interest related to the study.","ALL","50 Years","80 Years",{"count":191,"type":192},376,"ESTIMATED","INTERVENTIONAL",[195],"NA","This multicenter, prospective, open-label, blinded-endpoint, randomized controlled trial is to evaluate the efficacy and safety of deep cervical lymphatic venous anastomosis (DC-LVA) plus usual care versus usual care in reduing the score of clinical dementia rating-sum of boxes (CDR-SB) at 12 months in patients with moderate-to-severe Alzheimer's Disease (AD).",[198],"Alzheimers Disease",[200,201,202],"Alzheimers disease","Cervical Lymphatic Venous Anastomosis","Randomized Controlled Trial","2026-05-08",{"date":205,"type":206},"2026-05-12","ACTUAL",{"date":208,"type":206},"2026-03-13",{"date":210,"type":192},"2029-11-30",{"name":5,"class":6},9]