[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582282":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":16,"armGroups":17,"interventions":13,"overallOfficials":13,"centralContacts":22,"locations":28,"responsibleParty":42,"collaborators":46,"id":51,"slug":13,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":13,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":57,"maxAge":13,"enrollmentInfo":58,"targetDuration":13,"studyType":61,"phases":13,"briefSummary":62,"conditions":63,"keywords":13,"overallStatus":31,"whyStopped":13,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"Shanghai 6th People's Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"The agreement between the simulated short-term clinical outcomes in the virtual clinical studies and the real-world short-term clinical outcomes in the real-world clinical studies","We will use three predefined binary metrics to evaluate the agreement: (1) full statistical significance agreement, defined by effect estimates and CIs of the virtual and real-world clinical studies on the same side of the null; (2) estimate agreement, defined by whether effect estimates for the virtual clinical studies fell within the 95% CI for the real-world clinical study results; (3) standardized difference agreement between treatment effect estimates from the real-world clinical studies and the virtual clinical studies, defined by standardized differences (Reference: JAMA. 2023;329(16):1376-1385. doi:10.1001\u002Fjama.2023.4221).","Within 3 months",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":6,"timePerspective":15,"maskingInfo":13},"PROSPECTIVE","We will mainly include participants at high-risk of or with chronic diseases.",[18,20],{"label":19,"type":13,"description":13,"interventionNames":13},"Virtual clinical studies",{"label":21,"type":13,"description":13,"interventionNames":13},"Real-world clinical studies",[23],{"name":24,"role":25,"phone":26,"phoneExt":13,"email":27},"Huating Li, MD, PhD","CONTACT","+86-17749716891","huarting99@sjtu.edu.cn",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":13,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":13},"Shanghai Health and Medical Center","RECRUITING","Wuxi","Jiangsu","China","CN",{"type":37,"coordinates":38},"Point",[39,40],120.28857,31.56887,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":13,"oldOrganization":13},"PRINCIPAL_INVESTIGATOR","Li Huating","Professor",[47,49],{"name":48,"class":6},"Tsinghua University",{"name":50,"class":6},"Shanghai Jiao Tong University School of Medicine","100582282",false,"NCT06861283","Development and Validation of a Digital Twin-based Clinical Research System (X Town Stage I)","Inclusion Criteria:\n\n1. Age≥18 years old\n2. Receiving care at a community health service centre\n3. Able to understand and comply with the study procedures\n4. Agrees to participate in the study and signs the informed consent form\n\nExclusion Criteria:\n\n1. Patients with severe mental illness\n2. Patients expected to be unable to complete follow-ups","ALL","18 Years",{"count":59,"type":60},1500,"ESTIMATED","OBSERVATIONAL","Chronic diseases, characterized by their prolonged duration and slow progression, have emerged as predominant contributors to global morbidity and mortality. The investigators have developed a digital twin-based clinical research system (termed X Town) for chronic diseases, to predict clinical outcomes under various interventions. In this study, the investigators aim to evaluate the reliability of the developed digital twin-based clinical research system in predicting short-term clinical outcomes via virtual and real-world clinical studies.",[64],"Chronic Disease","2025-05-14",{"date":67,"type":68},"2025-05-15","ACTUAL",{"date":70,"type":68},"2025-04-13",{"date":72,"type":60},"2025-08-10",{"name":5,"class":6},1]