[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563181":3},{"organization":4,"outcomesModule":7,"designInfo":14,"detailedDescription":13,"studyPopulation":17,"armGroups":18,"interventions":24,"overallOfficials":13,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":13,"id":53,"slug":13,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":13,"enrollmentInfo":61,"targetDuration":13,"studyType":64,"phases":13,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":38,"whyStopped":13,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Centre Francois Baclesse","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":13},[9],{"measure":10,"description":11,"timeFrame":12},"Rate of establishment of exploitable tumor organoids","Rate of establishment usable tumor organoids for predictive tests of response to treatment.","through study completion, an average of 3 years",null,{"allocation":13,"interventionModel":13,"interventionModelDescription":13,"primaryPurpose":13,"observationalModel":15,"timePerspective":16,"maskingInfo":13},"COHORT","PROSPECTIVE","Patient with undifferentiated primary carcinoma (UPC) with indication for 1st-line treatment",[19],{"label":20,"type":13,"description":21,"interventionNames":22},"Blood and tumor collection","Blood and tumor collection before treatment initiation",[23],"Other: organoid etablishment",[25],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":13},"organoid etablishment","Prior to initiation of 1st-line therapy:\n\n* Collection of an additional study-specific tumor sample for tumoroid analysis (1 fresh tumor sample)\n* A blood test blood a for tumoroid realization and :\n* Analysis of ex vivo tumoroid response to treatment and correlation with patient response in vivo\n* Analysis of correlation between in vivo and ex vivo tumor characteristics\n* Analysis of first- and second-line survival rates and overall survival",[20],[30],{"name":31,"role":32,"phone":33,"phoneExt":13,"email":34},"zoé NEVIERE, Medical Doctor","CONTACT","33231455050","z.neviere@baclesse.unicancer.fr",[36],{"facility":37,"status":38,"city":39,"state":13,"zip":13,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Centre François Baclesse","RECRUITING","Caen","France","FR",{"type":43,"coordinates":44},"Point",[45,46],-0.35912,49.18585,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":33,"phoneExt":13,"email":34},"Zoé NEVIERE, MD",{"type":52,"investigatorFullName":13,"investigatorTitle":13,"investigatorAffiliation":13,"oldNameTitle":13,"oldOrganization":13},"SPONSOR","100563181",false,"NCT06612827","Development of Tumor Organoids From Undifferentiated Primary Carcinomas to Guide Therapeutic Decisions","OCAPI","Inclusion Criteria:\n\n* Patient with undifferentiated primary carcinoma (UPC) with histological and immunohistochemical evidence, validated in a local and\u002For national UPC multidisciplinary consultation\n* Patient with indication for systemic 1st-line treatment at the time of inclusion. Treatment may already have begun at the time of inclusion, but within the limit of 2 treatment cycles administered.\n* Patient with life expectancy greater than 3 months\n* Patient of legal age\n* Patient affiliated to a social security scheme\n* Signature of informed consent prior to any specific study procedure\n\nExclusion Criteria:\n\n* Persons deprived of their liberty or under guardianship (including curatorship)\n* Pregnant or breast-feeding patient","ALL","18 Years",{"count":62,"type":63},20,"ESTIMATED","OBSERVATIONAL","The study is based on the constitution of a collection of tumor and blood samples for the development of tumoroid for functional tests to predict clinical response to treatment.",[67],"Undifferentiated Carcinoma",[69,70],"tumoroid","organoid","2025-12-23",{"date":73,"type":74},"2025-12-24","ACTUAL",{"date":76,"type":74},"2025-03-05",{"date":78,"type":63},"2032-12-15",{"name":5,"class":6},1]