[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586074":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":37,"locations":43,"responsibleParty":64,"collaborators":30,"id":67,"slug":30,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":30,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":30,"overallStatus":45,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Dexmedetomidine group","EXPERIMENTAL","Patients will receive 1 μg\u002Fkg of intravenous dexmedetomidine over 10 min followed by an intravenous infusion of 0.5 μg\u002Fkg\u002Fh.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Lidocaine group","Patients will receive a bolus of intravenous lidocaine 1.5mg\u002Fkg over 10 min followed by a continuous infusion of lidocaine 1.5mg\u002Fkg\u002Fh.",[18],"Drug: Lidocaine",{"label":20,"type":21,"description":22,"interventionNames":23},"Control group","PLACEBO_COMPARATOR","Patients will receive intravenous isotonic saline 0.9% in the same volume and manner as the study drugs.",[24],"Drug: Isotonic saline",[26,31,34],{"type":27,"name":28,"description":11,"armGroupLabels":29,"otherNames":30},"DRUG","Dexmedetomidine",[9],null,{"type":27,"name":32,"description":16,"armGroupLabels":33,"otherNames":30},"Lidocaine",[15],{"type":27,"name":35,"description":22,"armGroupLabels":36,"otherNames":30},"Isotonic saline",[20],[38],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},"Mohamed E Abdel Fattah, MD","CONTACT","00201284475792","mohamed-elsaid@cu.edu.eg",[44],{"facility":5,"status":45,"city":46,"state":30,"zip":47,"country":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Cairo","12613","Egypt",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56,57,60,62],{"name":39,"role":40,"phone":41,"phoneExt":30,"email":42},{"name":58,"role":59,"phone":30,"phoneExt":30,"email":30},"Samuel F Samy, MD","PRINCIPAL_INVESTIGATOR",{"name":61,"role":59,"phone":30,"phoneExt":30,"email":30},"Norma O Zayed, MD",{"name":63,"role":59,"phone":30,"phoneExt":30,"email":30},"Mohammed ElSharkawy, MD",{"type":59,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Mohamed Elsaid Abdel Fattah","Lecturer of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, National Cancer Institute, Cairo University, Egypt.","100586074",false,"NCT06910644","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy","Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status II.\n* Scheduled for mastectomy with axillary dissection (either modified radical mastectomy with or without latissimus dorsi flap or conservative breast surgery) due to breast cancer.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Known allergy to any of the study drugs.\n* Those with hepatic or renal insufficiency.\n* Patients who are running regularly on B blockers.\n* α2 adrenergic agonists and sedatives.\n* Psychoactive medications.","FEMALE","18 Years","75 Years",{"count":77,"type":78},90,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.",[28,32,84,85,86,87,88],"Infusion","Adjuvants","General Anesthesia","Chronic Pain","Mastectomy","2025-04-05",{"date":91,"type":92},"2025-04-08","ACTUAL",{"date":89,"type":92},{"date":95,"type":78},"2025-12-01",{"name":5,"class":6},1]