[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100283059":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":65,"collaborators":10,"id":68,"slug":10,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14,17,20,23,26,29],{"label":9,"type":10,"description":11,"interventionNames":12},"Progressive supranuclear palsy",null,"Observational Study",[13],"Other: Observational Study",{"label":15,"type":10,"description":11,"interventionNames":16},"Corticobasal syndrome",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Behavoral variant FTD",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Semantic variant PPA",[13],{"label":24,"type":10,"description":11,"interventionNames":25},"Non-fluent variant PPA",[13],{"label":27,"type":10,"description":11,"interventionNames":28},"FTD-motor neuron disease",[13],{"label":30,"type":10,"description":11,"interventionNames":31},"Healthy controls",[13],[33],{"type":6,"name":11,"description":10,"armGroupLabels":34,"otherNames":10},[18,15,27,30,24,9,21],[36],{"name":37,"affiliation":38,"role":39},"Maria C Tartaglia, M.D.","Toronto Western Hospital, UHN; Tanz CRND","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":10,"email":45},"Cristina Salvo, BSc, MD","CONTACT","416-507-6880","cristina.salvo@uhn.ca",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Toronto Western Hospital, University Health Network","RECRUITING","Toronto","Ontario","M5T 2S8","Canada",{"type":55,"coordinates":56},"Point",[57,58],-79.39864,43.70643,{"lat":58,"lon":57},[61],{"name":62,"role":43,"phone":63,"phoneExt":10,"email":64},"Carmela Tartaglia, MD","416-603-5483","carmela.tartaglia@uhn.ca",{"type":39,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Carmela Tartaglia","Principal Investigator","100283059",false,"NCT02964637","Diagnosing Frontotemporal Lobar Degeneration","Multimodal Assessment for Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration","Inclusion Criteria:\n\n* Participant must have a reliable study partner who can provide an independent evaluation of functioning.\n* Able to read, understand and speak English for neuropsychological testing.\n* All subjects must meet one of these diagnostic criteria (A) probable behavioral variant FTD, (B) MRI-supported non-fluent variant PPA; (C) MRI-supported semantic variant PPA and \\[18F\\]T807 negative (D) probable CBS: using current criteria for CBS(27); (E) PSP: inclusion criteria for PSP are based upon the National Institute of Neurological Disorders and Stroke Society of Progressive Supranuclear Palsy (NINDS-SPSP) (F) FTD-MND\n* Control subjects must have a normal neurological exam, a CDR sum of boxes = 0, and MMSE score equal to or greater than 28\n\nExclusion Criteria:\n\n* Patients with clinical, imaging or CSF A beta\u002F tau profile consistent with AD\n* History of traumatic brain injury, brain tumors, stroke or other neurological or psychiatric disorders that can explain symptoms will be excluded.\n* Premenopausal women will be asked to consent to a pregnancy test prior to each scan as pregnant women will be excluded from study because of potential harm to fetus from PET study.\n* Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body.",true,"ALL","18 Years","90 Years",{"count":79,"type":80},100,"ESTIMATED","OBSERVATIONAL","To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes",[84,85,86,87,88,89],"Corticobasal Syndrome","Progressive Supranuclear Palsy","Behavioral Variant Frontotemporal Dementia","Semantic Dementia","Progressive Nonfluent Aphasia","Amyotrophic Lateral Sclerosis And\u002For Frontotemporal Dementia","2025-03-25",{"date":92,"type":93},"2025-03-30","ACTUAL",{"date":95,"type":10},"2015-08",{"date":97,"type":80},"2026-12",{"name":5,"class":6},1]