Diagnosing Variable Primary Aldosteronism.
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorQueen Mary University of London
About this trial
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
Eligibility criteria
Qualifiers
People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity <0.5 nmol/h/L or renin mass <5 ng/L), plasma sodium > 140mmol/L or plasma potassium < 4mmol/L.
Patients who have been diagnosed with PA and had previous aldosterone samples <277 pmol/L, a level which would normally not qualify for confirmatory testing.
Patients with aldosterone results done at different times that indicate variability in production.
Willing to consent and participate in the study.
Disqualifiers
Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
People on end of life treatment.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Locations
1Queen Mary University of London London United Kingdom
Sponsors and collaborators
Queen Mary University of London
Lead sponsor
Source ClinicalTrials.gov