[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100498094":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":34,"collaborators":7,"id":36,"slug":7,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":7,"eligibilityCriteria":41,"healthyVolunteers":37,"sex":42,"minAge":43,"maxAge":7,"enrollmentInfo":44,"targetDuration":7,"studyType":47,"phases":7,"briefSummary":48,"conditions":49,"keywords":7,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":61},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"William Drake, Prof","PRINCIPAL_INVESTIGATOR",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":7,"email":17},"Yun Ni Lee","CONTACT","+442078827275","y.n.lee@qmul.ac.uk",{"name":19,"role":15,"phone":16,"phoneExt":7,"email":20},"Tumi Kaminskas","research.governance@qmul.ac.uk",[22],{"facility":5,"status":23,"city":24,"state":7,"zip":7,"country":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"RECRUITING","London","United Kingdom",{"type":27,"coordinates":28},"Point",[29,30],-0.12574,51.50853,{"lat":30,"lon":29},[33],{"name":14,"role":15,"phone":7,"phoneExt":7,"email":17},{"type":35,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100498094",false,"NCT05765786","Diagnosing Variable Primary Aldosteronism.","Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?","Inclusion Criteria:\n\n* People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity \\\u003C0.5 nmol\u002Fh\u002FL or renin mass \\\u003C5 ng\u002FL), plasma sodium \\> 140mmol\u002FL or plasma potassium \\\u003C 4mmol\u002FL.\n* Patients who have been diagnosed with PA and had previous aldosterone samples \\\u003C277 pmol\u002FL, a level which would normally not qualify for confirmatory testing.\n* Patients with aldosterone results done at different times that indicate variability in production.\n* Willing to consent and participate in the study.\n\nExclusion Criteria:\n\n* Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.\n* People on end of life treatment.","ALL","18 Years",{"count":45,"type":46},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.",[50,51],"Primary Aldosteronism","High Blood Pressure","2026-06-12",{"date":54,"type":55},"2026-06-15","ACTUAL",{"date":57,"type":55},"2023-02-24",{"date":59,"type":46},"2027-07-24",{"name":5,"class":6},1]