[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100604574":3},{"organization":4,"outcomesModule":7,"designInfo":24,"detailedDescription":23,"studyPopulation":27,"armGroups":28,"interventions":37,"overallOfficials":23,"centralContacts":55,"locations":23,"responsibleParty":61,"collaborators":23,"id":65,"slug":23,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":23,"eligibilityCriteria":69,"healthyVolunteers":66,"sex":70,"minAge":71,"maxAge":23,"enrollmentInfo":72,"targetDuration":23,"studyType":75,"phases":23,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":85,"whyStopped":23,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":23},{"fullName":5,"class":6},"Xiangya Hospital of Central South University","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":19,"otherOutcomes":23},[9,13,16],{"measure":10,"description":11,"timeFrame":12},"Sensitivity and specificity of TCCD","Sensitivity and specificity of diagnosing intracranial hypertension using TCCD","Day 0 (when invasive ICP probe is implanted) to day 10",{"measure":14,"description":15,"timeFrame":12},"Sensitivity and specificity of ONSD","Sensitivity and specificity of diagnosing intracranial hypertension using ONSD",{"measure":17,"description":18,"timeFrame":12},"Sensitivity and specificity of ODH","Sensitivity and specificity of diagnosing intracranial hypertension using ODH",[20],{"measure":21,"description":22,"timeFrame":12},"Pearson correlation coefficient between ultrasound metrics and invasive ICP","Pearson correlation coefficient between metrics from bedside ultrasound and invasive ICP",null,{"allocation":23,"interventionModel":23,"interventionModelDescription":23,"primaryPurpose":23,"observationalModel":25,"timePerspective":26,"maskingInfo":23},"CASE_ONLY","CROSS_SECTIONAL","The study selects patients admitted to the neurosurgical intensive care unit of Central South University Xiangya Hospital.",[29],{"label":30,"type":23,"description":31,"interventionNames":32},"Patients with traumatic brain injury and invasive ICP monitoring","Patients with traumatic brain injury and invasive ICP monitoring.",[33,34,35,36],"Diagnostic Test: TCCD","Diagnostic Test: ONSD","Diagnostic Test: ODH","Diagnostic Test: Invasive ICP",[38,43,47,51],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":23},"DIAGNOSTIC_TEST","TCCD","Patients receive non-invasive assessments of TCCD using bedside ultrasound.",[30],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":23},"ONSD","Patients receive non-invasive assessments of ONSD using bedside ultrasound.",[30],{"type":39,"name":48,"description":49,"armGroupLabels":50,"otherNames":23},"ODH","Patients receive non-invasive assessments of ODH using bedside ultrasound.",[30],{"type":39,"name":52,"description":53,"armGroupLabels":54,"otherNames":23},"Invasive ICP","Patients receive invasive assessments of ICP.",[30],[56],{"name":57,"role":58,"phone":59,"phoneExt":23,"email":60},"Ziyuan Liu, M.D.","CONTACT","86-151-1137-3960","ethmery@yeah.net",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Jinfang Liu, MD","Director of the Neurotrauma and Neurointensive Care Group","100604574",false,"NCT07151287","Diagnosis of Intracranial Hypertension Using TCCD, ONSD and ODH by Bedside Ultrasound","Inclusion Criteria:\n\n* Traumatic brain injury;\n* Received invasive ICP monitoring;\n* age ≥ 18 years old.\n\nExclusion Criteria:\n\n* Severe eyeball \u002F eyelid damage prevents transorbital ultrasound examination;\n* Allergy to ultrasound coupling agent;\n* Pregnant or lactating females.","ALL","18 Years",{"count":73,"type":74},64,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to investigate several means of measuring intracranial pressure (ICP) non-invasively in patients who had head trauma and received implantation of invasive ICP monitor device. The main questions it aims to answer are:\n\nWhat are the diagnostic efficacies of Transcranial Color-Coded Doppler Ultrasound (TCCD), Optic Nerve Sheath Diameter (ONSD) and Optic Disc Height (ODH) (the 3 non-invasive way of measuring ICP) compared with invasive ICP monitor? Participants will receive simultaneous non-invasive measurements of TCCD, ONSD and ODH along with during the days of invasive ICP monitoring. The data will be compared among the techniques to study the diagnostic efficacy.",[78],"Traumatic Brain Injury",[80,81,82,83,84],"traumatic brain injury","craniocerebral trauma","brain trauma","intracranial pressure","transcranial Doppler ultrasound","NOT_YET_RECRUITING","2025-09-01",{"date":88,"type":89},"2025-09-03","ACTUAL",{"date":91,"type":74},"2025-09-15",{"date":93,"type":74},"2027-07-01",{"name":5,"class":6}]