[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611922":3},{"organization":4,"outcomesModule":7,"designInfo":25,"detailedDescription":31,"studyPopulation":20,"armGroups":32,"interventions":44,"overallOfficials":20,"centralContacts":20,"locations":20,"responsibleParty":54,"collaborators":20,"id":58,"slug":20,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":61,"acronym":20,"eligibilityCriteria":62,"healthyVolunteers":59,"sex":63,"minAge":64,"maxAge":20,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":20,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":20},{"fullName":5,"class":6},"China-Japan Friendship Hospital","OTHER",{"primaryOutcomes":8,"secondaryOutcomes":13,"otherOutcomes":20},[9],{"measure":10,"description":11,"timeFrame":12},"The granuloma detection rate","The number of patients with granulomas detected relative to the total number of patients tested.","7 days after sampling",[14,18,22],{"measure":15,"description":16,"timeFrame":17},"Diagnostic yield","The proportion of all participants who underwent the diagnostic procedure in whom a specific malignant or benign diagnosis was established","6 Month after sampling",{"measure":19,"description":20,"timeFrame":21},"Negative predictive value",null,"6 months after sampling",{"measure":23,"description":20,"timeFrame":24},"Incidence of complications","4 weeks after sampling",{"allocation":26,"interventionModel":27,"interventionModelDescription":20,"primaryPurpose":28,"observationalModel":20,"timePerspective":20,"maskingInfo":29},"RANDOMIZED","PARALLEL","DIAGNOSTIC",{"masking":30,"maskingDescription":20,"whoMasked":20},"NONE","Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and\u002For transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. Two questions remain need to be answered: (1) Does EBUS-TBMC have the same or better diagnostic sensitivity for sarcoidosis than EBUS-TBNA combined with standard bronchoscopic modalities (EBB or\u002Fand TBLB)? (2) Can combining EBUS-TBMC with standard bronchoscopic modalities further increase the diagnostic sensitivity for sarcoidosis? This study is designed as a randomised controlled trial to compare the diagnostic yield between EBUS-TBMC and conventional bronchoscopic approaches for diagnosing stage I\u002FII sarcoidosis.",[33,39],{"label":34,"type":35,"description":36,"interventionNames":37},"EBUS-TBMC","EXPERIMENTAL","Patients will receive endobronchial biopsy, transbronchial lung biopsy and EBUS-TBMC",[38],"Procedure: EBUS-TBMC based sampling method",{"label":40,"type":35,"description":41,"interventionNames":42},"EBUS-TBNA","Patients will receive endobronchial biopsy, transbronchial lung biopsy and EBUS-TBNA",[43],"Procedure: EBUS-TBNA-based sampling methods",[45,50],{"type":46,"name":47,"description":48,"armGroupLabels":49,"otherNames":20},"PROCEDURE","EBUS-TBNA-based sampling methods","Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBNA.",[40],{"type":46,"name":51,"description":52,"armGroupLabels":53,"otherNames":20},"EBUS-TBMC based sampling method","Participants will receive an endobronchial biopsy and a transbronchial lung biopsy, followed by EBUS-TBMC.",[34],{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Gang Hou","Principal Investigator","100611922",false,"NCT07246876","Diagnostic Value of EBUS-Guided Transbronchial Mediastinal Cryobiopsy Versus Conventional Bronchoscopic Approaches for Stage I\u002FII Sarcoidosis","Inclusion Criteria:\n\n1. Age ≥18years;\n2. Patients with clinical and radiological suspicion of stage I or stage II sarcoidosis;\n3. Fully informed of the purpose and method of the study\n\nExclusion Criteria:\n\n1. Pathologically confirmed sarcoidosis, obvious organ involvement with the possibility of confirming granulomas using a minimally invasive diagnostic procedure;\n2. Patients with medical contraindications to bronchoscopy procedures.","ALL","18 Years",{"count":66,"type":67},469,"ESTIMATED","INTERVENTIONAL",[70],"NA","Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), combined with endobronchial biopsy (EBB) and\u002For transbronchial lung biopsy (TBLB), and endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy (EBUS-TBMC) have high diagnostic yields for patients with sarcoidosis. However, a direct comparison between them has not been conducted. This randomized controlled trial aims to compare directly the diagnostic yield between EBUS-TBMC and EBUS-TBNA+EBB+TBLB in sarcoidosis.",[73],"Sarcoidosis, Pulmonary",[75,40,76,77],"Endobronchial Ultrasound","EBUS-transbronchial mediastinal cryobiopsy","Sarcoidosis","NOT_YET_RECRUITING","2026-02-04",{"date":81,"type":82},"2026-02-06","ACTUAL",{"date":84,"type":67},"2026-03-01",{"date":86,"type":67},"2026-12",{"name":5,"class":6}]